Evidence map›Paper›PMID 39404261›Full record

ArticlemSphere2024

Effect of C-to-T transition at CpG sites on tumor suppressor genes in tumor development in cattle evaluated by somatic mutation analysis in enzootic bovine leukosis.

Asami Nishimori, Kiyohiko Andoh, Yuichi Matsuura, Tomohiro Okagawa, Satoru Konnai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mSphere, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Asami NishimoriNational Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Japan.ORCID 0000-0003-3936-7515
Kiyohiko AndohNational Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Japan.ORCID 0000-0001-7659-8692
Yuichi MatsuuraNational Institute of Animal Health, National Agriculture and Food Research Organization, Tsukuba, Japan.
Tomohiro OkagawaDepartment of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.
Satoru KonnaiDepartment of Advanced Pharmaceutics, Faculty of Veterinary Medicine, Hokkaido University, Sapporo, Hokkaido, Japan.ORCID 0000-0002-3230-7109

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Oncogenic transformation of normal cells is caused by mutations and chromosomal abnormalities in cancer-related genes. Enzootic bovine leukosis (EBL) is a malignant B-cell lymphoma caused by bovine leukemia virus (BLV) infection in cattle. Although a small fraction of BLV-infected cattle develops EBL after a long latent period, the mechanisms for oncogenesis in EBL cattle remain largely unknown. In this study, we analyzed the types and patterns of somatic mutations in cancer cells from 36 EBL cases, targeting 21 cancer-related genes. Various somatic mutations were identified in eight genes,

Indexed as

Enzootic Bovine LeukosisGenes, Tumor SuppressorLeukemia Virus, BovineMutationAnimalsCarcinogenesisCattleCpG IslandsDNA Mutational Analysisenzootic bovine leukosismutation signaturesomatic mutationTP53

Identifiers

PMID39404261
PMCPMC11580432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.