Evidence map›Paper›PMID 39404196›Full record

ArticleAIDS care2025

A qualitative dyad analysis of barriers and facilitators of antiretroviral therapy (ART) adherence among people who inject drugs (PWID) with HIV in Kazakhstan.

Paige Neuenschwander, Fredrick L Altice, Robert H Remien, Gaukhar Mergenova, Lyailya Sarsembayeva, Elena Rozental, Valeriy Gulyayev, Alissa Davis

Abstract read
In one paragraph

Article in AIDS care, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

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0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

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2 · The registry

The trial behind it

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3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Paige NeuenschwanderSchool of Public Health, State University of New York-Downstate Health Science University, Brooklyn, NY, USA.
Fredrick L AlticeSection of Infectious Diseases, Department of Medicine, Yale University, New Haven, CT, USA.
Robert H RemienDivision of Gender, Sexuality & Health, HIV Center, New York State Psychiatric Institute and Columbia University Irving Medical Center, New York, NY, USA.
Gaukhar MergenovaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Lyailya SarsembayevaGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Elena RozentalGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Valeriy GulyayevGlobal Health Research Center of Central Asia, Almaty, Kazakhstan.
Alissa DavisSchool of Social Work, Columbia University, New York, NY, USA.

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
A couple-based antiretroviral therapy adherence intervention for people who inject drugs in KazakhstanK01DA044853 · NIDA · COLUMBIA UNIV NEW YORK MORNINGSIDE · PI DAVIS, ALISSA · 2018 to 2022
$903k
NCATS NIH HHS UL1 TR001863NIDA NIH HHS K01 DA044853NIDA NIH HHS L30 DA049137
6 · The paper itself

Abstract

People with HIV (PWH) who inject drugs (PWID) face many barriers to ART adherence. Kazakhstan has one of the fastest growing HIV epidemics in the world, primarily fueled by injection drug use, yet ART adherence among PWID is low. Social support can help address these barriers, but ART adherence among PWID is rarely examined within the relationship context. We conducted interviews with 20 PWID with HIV and 18 of their intimate partners and performed a qualitative dyad analysis to examine ART adherence factors. The results indicated many barriers and facilitators of ART adherence at the individual level (e.g., substance use), interpersonal level (e.g., social support) and structural level (e.g., stigma, transportation). Reported adherence barriers and facilitators had high congruence between dyad members; however, some notable differences were found between dyads. Compared to PWH, partners without HIV had a lack of awareness about the role of stigma in impeding ART adherence. Different manifestations of social support to facilitate ART adherence were noted between seroconcordant dyads (e.g., taking pills together, attending appointments together) and serodiscordant dyads (e.g., reminders to take pills, providing babysitting to enable attendance at doctor appointments). Future research and programs may benefit from integrating dyad approaches into ART adherence interventions.

Indexed as

Drug MonitoringHIV InfectionsMedication AdherenceQualitative ResearchSocial StigmaSocial SupportSubstance Abuse, IntravenousAdultAnti-HIV AgentsFemaleHumansInterviews as TopicKazakhstanMaleMiddle AgedSexual PartnersAnti-HIV AgentsART adherencedyadHIVPeople who inject drugsSDG 10: reduced inequalities

Identifiers

PMID39404196
PMCPMC11682916

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.