Evidence map›Paper›PMID 39403914›Full record

ArticleActas espanolas de psiquiatria2024

Electroconvulsive Therapy Regulates the Interhemispheric Functional Connectivity of the Dorsomedial Prefrontal Cortex in Depressive Patients: Evidence from 2 Independent Samples.

Loufeng Zhang, Yuanyuan Guo, Tongjian Bai, Meidan Zu, Qiang Wei, Yue Wu, Gongjun Ji, Huaming Lv, Wen Xie, Kai Wang and 2 more

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Article in Actas espanolas de psiquiatria, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

12 authors.

Loufeng ZhangDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, China; Department of Geriatric Psychology, The Fourth People's Hospital of Hefei, 230000 Hefei, Anhui, China.
Yuanyuan GuoDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, China.
Tongjian BaiDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, China.
Meidan ZuDepartment of Medical Psychology and Sleep, The Second Affiliated Hospital of Anhui Medical University, 230601 Hefei, Anhui, China.
Qiang WeiDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, China.
Yue WuDepartment of Medical Psychology and Sleep, The Second Affiliated Hospital of Anhui Medical University, 230601 Hefei, Anhui, China.
Gongjun JiAnhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, 230022 Hefei, Anhui, China; Hefei Collaborative Innovation Center of Neuropsychiatric Disorders and Mental Health, 230022 Hefei, Anhui, China.
Huaming LvDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, China.
Wen XieDepartment of Anxiety and Depression, Anhui Mental Health Center, 230000 Hefei, Anhui, China.
Kai WangDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, China; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, 230022 Hefei, Anhui, China.
Yanghua TianDepartment of Neurology, The First Affiliated Hospital of Anhui Medical University, 230022 Hefei, Anhui, China; Department of Medical Psychology and Sleep, The Second Affiliated Hospital of Anhui Medical University, 230601 Hefei, Anhui, China; Anhui Province Key Laboratory of Cognition and Neuropsychiatric Disorders, 230022 Hefei, Anhui, China.
Jingyong SuThe College of Computer Science and Technology, Harbin Institute of Technology, 518055 Shenzhen, Guangdong, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe dorsomedial prefrontal cortex (dmPFC) is considered a crucial node in emotional and cognitive processes. Voxel-mirrored homotopic connectivity (VMHC) is a validated methodology for investigating interhemispheric coordination. This study aims to elucidate the effects of electroconvulsive therapy (ECT) on the interhemispheric connectivity of the dmPFC in patients with depression, using VMHC as a measure of bilateral neural coordination.

methodsThirty-three patients with depression, screened at the University of Science and Technology of China (USTC), and thirty-five patients with depression, screened at Anhui Medical University (AHMU), were selected as the subjects of this study. VMHC was employed to investigate the effects of ECT on bilateral hemispheric functional connectivity. The Hamilton Depression Rating Scale (HAMD) was used to assess depressive symptoms, and the relationships between changes in HAMD scores and VMHC values were examined.

resultsFollowing ECT, the depressive symptoms of all participants decreased (p < 0.001). The VMHC values in the dmPFC were significantly increased in both groups after ECT (p < 0.01). No significant correlation was found between the increasing VMHC values in the dmPFC and the changes in HAMD scores in depressed patients (p > 0.05).

conclusionThese results show that ECT regulates interhemispheric functional connectivity in depressed patients, and significantly increases the VMHC values in the dmPFC. Our findings may provide a useful method for optimizing the treatment of depression.

Indexed as

Electroconvulsive TherapyPrefrontal CortexAdultDepressionFemaleHumansMagnetic Resonance ImagingMaleMiddle Aged

Identifiers

PMID39403914
PMCPMC11474968

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.