ReviewHeliyon2024
The efficacy and potential mechanism of the acupuncture treatment for allergic rhinitis: A systematic review and meta-analysis of data from animal models.
Review in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
3 citing papers in PubMed, 1 synthesis or guideline pooled it.
- The effect of tanshinones on cognitive impairments in animal models of Alzheimer's disease: a systematic review and meta-analysis.Frontiers in pharmacology · 2025Pooled it
- A 90-day safety study of meat from MSTN gene-edited Mongolian cattle in mice.Scientific reports · 2026Article
- Efficacy and Proposed Mechanisms of Electroacupuncture in Animal Models of Chemotherapy-Induced Peripheral Neuropathy: A Systematic Review and Meta-Analysis.Journal of pain research · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to evaluate the efficacy of acupuncture in treating allergic rhinitis (AR) in animal models of the disease, and to explore the underlying mechanism of acupuncture in AR. Methods: Related literature was retrieved from multiple databases, including China National Knowledge Infrastructure (CNKI), Wan Fang databases, SinoMed databases, VIP database, PubMed, EMBASE, the Cochrane Library, up to September 2023. The inclusion criteria were focused on animal experiments that investigated the effect of acupuncture therapy on animal models of AR. Studies combining acupuncture with other Chinese medicine therapies were excluded. Data were extracted independently by two reviewers using standardized forms. A total of 75 studies were finally included. The risk of bias in individual studies was evaluated using the Systematic Review Centre for Laboratory animal Experimentation (SYRCLE) tool, and the quality of reporting was evaluated according to Animal Research: Reporting of In Vivo Experiments (ARRIVE) guidelines. Meta-analyses and plotting were conducted using STATA 17.0 and RevMan 5.4. When heterogeneity was present, a random effects model was applied. Subgroup, meta-regression and sensitivity analyses were also performed. Results: The SYRCLE scores ranged from 3 to 7, and the ARRIVE scores ranged from 6.5 to 11 points. Meta-analysis results demonstrated that acupuncture could significantly down-regulate EOS counts in both blood and nasal mucosa, and reduce the serum levels of IL-5, compared to the AR model group. The results of the qualitative analysis showed that acupuncture could reduce the behavior scores of AR, down-regulate serum levels of IL-4, IgE and sIgE, as well as up-regulate IFN-γ levels. Subgroup analysis results suggested that the different interventions might contribute to the observed heterogeneity. Conclusion: Our results demonstrate that acupuncture effectively alleviates the nasal allergic symptoms in animal models, inhibits immune and inflammatory signaling transduction, and reduces the release of inflammatory mediators. This study highlights the potential of acupuncture as a promising therapeutic option for AR, however, further studies are required to fully understand its mechanisms of action.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.