Evidence map›Paper›PMID 39403494›Full record

ArticleHeliyon2024

Griffithazanone A, a sensitizer of EGFR-targeted drug in

Ting Xiao, Yuxin Zhu, Liang Zhang, Kaidi Xiao, Xiao Jia, Yashu Liu, Junfang Bi, Xiaoping Li, Honggang Zhou, Cheng Yang

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ting XiaoState Key Laboratory of Separation Membranes and Membrane Processes, Tianjin Key Laboratory of Green Chemical Technology and Process Engineering, School of Pharmaceutical Sciences, Tiangong University, Tianjin, 300387, China.
Yuxin ZhuState Key Laboratory of Medicinal Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Department of Thoracic Surgery, Tianjin First Central Hospital, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China.
Liang ZhangState Key Laboratory of Medicinal Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Department of Thoracic Surgery, Tianjin First Central Hospital, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China.
Kaidi XiaoState Key Laboratory of Medicinal Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Department of Thoracic Surgery, Tianjin First Central Hospital, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China.
Xiao JiaState Key Laboratory of Medicinal Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Department of Thoracic Surgery, Tianjin First Central Hospital, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China.
Yashu LiuState Key Laboratory of Medicinal Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Department of Thoracic Surgery, Tianjin First Central Hospital, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China.
Junfang BiDepartment of Combined Traditional Chinese Medicine and West Medicine, Traditional Chinese Medicine Hospital of Shijiazhuang City, Shijiazhuang, 050051, China.
Xiaoping LiState Key Laboratory of Medicinal Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Department of Thoracic Surgery, Tianjin First Central Hospital, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China.
Honggang ZhouState Key Laboratory of Medicinal Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Department of Thoracic Surgery, Tianjin First Central Hospital, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China.
Cheng YangState Key Laboratory of Medicinal Biology, College of Pharmacy and Tianjin Key Laboratory of Molecular Drug Research, Department of Thoracic Surgery, Tianjin First Central Hospital, Nankai University, Haihe Education Park, 38 Tongyan Road, Tianjin, 300353, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Non-small cell lung cancer (NSCLC), which accounts for up to 85 % of lung cancer cases, significantly impacts the health of individuals worldwide. While targeted therapy has played a crucial role, the emergence of EGFR resistance and adverse reactions has made it imperative to explore new medications. Natural products derived from plants became an important source of anti-tumor drugs. In this study, nine known compounds, including seven alkaloids (

Indexed as

ApoptosisGriffithazanone AOsimertinib resistantPIM1

Identifiers

PMID39403494
PMCPMC11471607

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.