Evidence map›Paper›PMID 39403455›Full record

ArticleHeliyon2024

Serum ferritin is a risk factor for pulmonary dysfunction in young patients with transfusion-dependent thalassemia.

Xiao Liang, Gaohui Yang, Lingling Shi, Lianjin Liu, Zhenbin Wei, Yumei Huang, Jing Bai, Yi Liang, Lingyuan Pan, Zhaoping Gan and 7 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Heliyon, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Xiao LiangDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Gaohui YangDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lingling ShiDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lianjin LiuDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhenbin WeiDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yumei HuangDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Jing BaiDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yi LiangDepartment of Respiratory and Critical Care Medicine, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Lingyuan PanDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Zhaoping GanDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yu LinDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yibin YaoDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Ying TangDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Huicheng HuangDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Xuemei ZhouDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Yongrong LaiDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.
Rongrong LiuDepartment of Hematology, The First Affiliated Hospital of Guangxi Medical University, Nanning, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research into the pulmonary function of patients with transfusion-dependent thalassemia (TDT) is limited, with existing studies presenting conflicting results. We carried out a retrospective study involving 140 patients with TDT. The mean patient age was 8.7 ± 3.2 years, with a median serum ferritin (SF) level of 3791.4 ng/ml (IQR: 2424.1-5733.3 ng/ml). Pulmonary function abnormalities were detected in 46.43 % (65 out of 140) of patients, primarily manifesting as diffusion dysfunction (26.43 %), followed by ventilatory dysfunction (5.0 %), and mixed pulmonary dysfunction (15.0 %). A serum ferritin level above 2500 ng/ml significantly correlated with the occurrence of these abnormalities(OR = 3.187, 95%CI:1.312-7.741, P = 0.010), while higher hemoglobin concentrations demonstrated a protective effect (OR = 0.966, 95%CI: 0.943-0.989, P = 0.004). Our study highlights diffusion dysfunction as the most prevalent type of pulmonary function abnormalities in TDT patients. Furthermore, it establishes a correlation between elevated serum ferritin levels and pulmonary dysfunction.

Indexed as

Iron overloadPulmonary functionSerum ferritinTransfusion-dependent thalassemia

Identifiers

PMID39403455
PMCPMC11471533

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.