Evidence map›Paper›PMID 39403384›Full record

ArticleFrontiers in immunology2024

Interleukin 9 mediates T follicular helper cell activation to promote antibody responses.

Taiki Sato, Ippei Ikegami, Masahiro Yanagi, Takeshi Ohyu, Taiki Sugaya, Shotaro Shirato, Masanobu Tanemoto, Shiori Kamiya, Kohei Kikuchi, Yuka Kamada and 7 more

Abstract read
In one paragraph

Article in Frontiers in immunology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Taiki Sato *Department of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Ippei Ikegami *Department of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Masahiro YanagiDepartment of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Takeshi OhyuDepartment of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Taiki SugayaDepartment of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Shotaro ShiratoDepartment of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Masanobu TanemotoDepartment of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Shiori KamiyaDepartment of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Kohei KikuchiDepartment of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Yuka KamadaDepartment of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Takehito NakataDepartment of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Ryuta KamekuraDepartment of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Akinori SatoDepartment of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.
Ken-Ichi TakanoDepartment of Otolaryngology and Head and Neck Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
Masahiro MiyajimaDepartment of Thoracic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
Atsushi WatanabeDepartment of Thoracic Surgery, Sapporo Medical University School of Medicine, Sapporo, Japan.
Shingo IchimiyaDepartment of Human Immunology, Research Institute for Immunology, Sapporo Medical University School of Medicine, Sapporo, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antigen-specific humoral responses are orchestrated through complex interactions among immune cells in lymphoid tissues, including the collaboration between B cells and T follicular helper (Tfh) cells. Accumulating evidence indicates a crucial role for interleukin-9 (IL-9) in the formation of germinal centers (GCs), enhancing the generation of class-switched high-affinity antibodies. However, the exact function of IL-9 in Tfh cell regulation remains unclear. In this study, we examined the humoral immune responses of CD4

Indexed as

Antibody FormationGerminal CenterInterleukin-9Lymphocyte ActivationT Follicular Helper CellsAnimalsAsthmaB-LymphocytesImmunoglobulin GMiceMice, Inbred C57BLMice, KnockoutSheepImmunoglobulin GInterleukin-9follicular mantle zone B cellsgerminal center responseIL-9ILC2leukotrienesT follicular helper cells

Identifiers

PMID39403384
PMCPMC11471543

What OpenQuestion holds

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LicenceCC BY
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.