Evidence map›Paper›PMID 39403354›Full record

ArticleBasic and clinical neuroscience

The Effects of IGF1 and MGF on Neural Stem Cells in Hypoxic Conditions.

Tuğba Aydıntuğ-Gürbüz, Fatih Toprak, Selin Toprak, Selçuk Sözer

Abstract read
In one paragraph

Article in Basic and clinical neuroscience. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Tuğba Aydıntuğ-GürbüzDepartment of Genetics, Aziz Sancar Research Institute of Experimental Medicine, Iıstanbul University, Çapa Campus, Iıstanbul, Turkey.ORCID https://orcid.org/0000-0001-8910-7055
Fatih ToprakDepartment of Neurosurgery, Haydarpaşa Numune Training and Research Hospital, Istanbul, Turkey.ORCID https://orcid.org/0000-0002-5232-6286
Selin ToprakDepartment of Genetics, Aziz Sancar Research Institute of Experimental Medicine, Iıstanbul University, Çapa Campus, Iıstanbul, Turkey.ORCID https://orcid.org/0000-0003-2882-3351
Selçuk SözerDepartment of Genetics, Aziz Sancar Research Institute of Experimental Medicine, Iıstanbul University, Çapa Campus, Iıstanbul, Turkey.ORCID https://orcid.org/0000-0002-5035-4048

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Ischemic stroke has high morbidity and mortality rates worldwide. Low oxygen (O Methods: An in vitro ischemia model was created by rat hippocampal NSC grown in culture that was exposed to varying oxygen levels, including 0%, 3%, and 20 % for the representation of anoxic, hypoxic, and normoxic conditions, respectively, during 24 h. NSC has investigated Results: Increased Conclusion: These findings suggest that IGF-I and MGF expressions were increased to reduce the damage in NSC exposed to low oxygen, and exogenous MGF and IGF-I application increased NSC proliferation at the time of injury. The results might imply the role of exogenous MGF and IGF-I in the treatment of ischemia for relieving the effect of neuronal damage due to their neuroprotective and proliferative effects.

Indexed as

Growth factorsHypoxiaInsulin-like growth factor 1 (IGF-I)Mechano growth factor (MGF)Neural stem cell (NSC)

Identifiers

PMID39403354
PMCPMC11470890

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.