Evidence map›Paper›PMID 39403090›Full record

ArticleRespirology case reports2024

Ramucirumab-induced ascites with endothelial growth factor receptor mutation-positive non-small cell lung cancer: Two case reports.

Keisuke Shiraha, Tomoki Tamura, Taisaku Koyanagi, Takahiro Umeno, Kazuya Nishii, Shoichi Kuyama

Abstract read
In one paragraph

Article in Respirology case reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Keisuke ShirahaDepartment of Respiratory Medicine NHO Iwakuni Clinical Center Iwakuni Japan.ORCID https://orcid.org/0009-0005-2383-9532
Tomoki TamuraDepartment of Respiratory Medicine NHO Iwakuni Clinical Center Iwakuni Japan.ORCID https://orcid.org/0000-0002-2480-9029
Taisaku KoyanagiDepartment of Respiratory Medicine NHO Iwakuni Clinical Center Iwakuni Japan.
Takahiro UmenoDepartment of Respiratory Medicine NHO Iwakuni Clinical Center Iwakuni Japan.
Kazuya NishiiDepartment of Respiratory Medicine NHO Iwakuni Clinical Center Iwakuni Japan.
Shoichi KuyamaDepartment of Respiratory Medicine NHO Iwakuni Clinical Center Iwakuni Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Ramucirumab (RAM) has been approved for the treatment of non-small cell lung cancer (NSCLC). Here, we report two cases of RAM-induced ascites with epidermal growth factor receptor-mutant NSCLC. Patient 1, a 72-year-old man, developed ascites 20 months after erlotinib (ERL) and RAM administration, which resolved after their discontinuation and performing paracentesis. Patient 2, an 83-year-old woman, developed ascites 9 months after ERL and RAM administration, which resolved after RAM discontinuation and furosemide administration. Ramucirumab administration can cause ascites due to increased hepatic sinusoidal pressure. Clinicians should be aware of RAM-induced ascites in patients with NSCLC and should appropriately manage it.

Indexed as

ascitesepidermal growth factor receptorerlotinibnon‐small cell lung cancerramucirumab

Identifiers

PMID39403090
PMCPMC11473188

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.