Evidence map›Paper›PMID 39403084›Full record

ArticleFrontiers in microbiology2024

Itaconate induces tolerance of

Runping Zhao, Lei Xu, Jieyun Chen, Yanxian Yang, Xilong Guo, Min Dai, Guo-Bao Tian, Li-Na Qin

Abstract read
In one paragraph

Article in Frontiers in microbiology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. The evolving landscape ofFrontiers in immunology · 2026
    Pooled it
  2. Review
  3. Itaconate and its derivatives in human health and diseases.Signal transduction and targeted therapy · 2026
    Review
  4. Review
  5. Article
  6. Role of itaconate in intestinal disease (Review).International journal of molecular medicine · 2026
    Review
  7. Article
  8. Review
  9. Article
  10. Reprogramming immunity with itaconate: metabolic mechanisms and therapeutic perspectives.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Runping Zhao *School of Laboratory Medicine, Chengdu Medical College, Chengdu, China.
Lei Xu *School of Laboratory Medicine, Chengdu Medical College, Chengdu, China.
Jieyun Chen *Zhongshan School of Medicine, Advanced Medical Technology Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Yanxian Yang *Zhongshan School of Medicine, Advanced Medical Technology Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Xilong GuoZhongshan School of Medicine, Advanced Medical Technology Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Min DaiSchool of Laboratory Medicine, Chengdu Medical College, Chengdu, China.
Guo-Bao TianZhongshan School of Medicine, Advanced Medical Technology Center, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.
Li-Na QinFaculty of Forensic Medicine, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Methods: In this study,the minimum inhibitory concentration (MIC) of the antibiotics against Results and discussion: According to the study,we found that the immune metabolite itaconate can induce tolerance in both methicillin-resistant and -susceptible

Indexed as

aminoglycosidesantibiotic toleranceimmune metaboliteitaconateStaphylococcus aureus

Identifiers

PMID39403084
PMCPMC11471559

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.