Evidence map›Paper›PMID 39403049›Full record

ReviewAlimentary pharmacology & therapeutics2024

Review article: Prevention of inflammatory bowel disease-The path forward.

Sérgio Bronze, Manasi Agrawal, Jean-Frédéric Colombel, Joana Torres, Ryan C Ungaro

Abstract readReview
In one paragraph

Review in Alimentary pharmacology & therapeutics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

  1. Article
  2. Article
  3. The 3 Ps of IBD today - prevention, pre-diagnosis and participation.Nature reviews. Gastroenterology & hepatology · 2026
    Article
  4. Article
  5. The global burden of inflammatory bowel disease: from 2025 to 2045.Nature reviews. Gastroenterology & hepatology · 2025
    Review
  6. Review
  7. Review
  8. Primary Prevention of Pouchitis.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2025
    Article
  9. Onset of pouchitis after colectomy for ulcerative colitis: reducing the risk.Expert review of gastroenterology & hepatology · 2025
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Sérgio BronzeGastroenterology and Hepatology Department, Unidade Local de Saúde de Santa Maria, Lisbon, Portugal.ORCID 0000-0001-8076-9706
Manasi AgrawalDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0003-4729-1485
Jean-Frédéric ColombelDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-6472-249X
Joana TorresFaculdade de Medicina de Lisboa, Universidade de Lisboa, Lisbon, Portugal.ORCID 0000-0003-2895-5821
Ryan C UngaroDivision of Gastroenterology, Department of Medicine, Icahn School of Medicine at Mount Sinai, New York, New York, USA.ORCID 0000-0001-8687-3758

Funding

Early-life Risk Factors for Inflammatory Bowel DiseaseK23DK129762 · NIDDK · ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI · PI AGRAWAL, MANASI · 2021 to 2025
$951k
NIDDK NIH HHS K23 DK129762
6 · The paper itself

Abstract

backgroundThe possibility of preventing inflammatory bowel disease (IBD) is becoming more plausible due to advances in understanding preclinical disease and successful prevention trials in other immune-mediated diseases, such as type 1 diabetes and rheumatoid arthritis. However, before that possibility becomes reality, several efforts need to occur in parallel and in a coordinated way.

aimTo propose some critical steps necessary for advancing the field of IBD prediction and prevention.

methodsWe reviewed the current literature to identify the necessary steps toward a preventive strategy for IBD.

resultsThe first step should determine the most robust predictive biomarkers and validate them across independent cohorts, creating a multidimensional predictive tool. The second step is to gain a better understanding of the preferences of first-degree relatives and people at risk for IBD, informing the implementation of screening and preventive strategies. Third, these efforts should contribute to the development of high-risk clinics and establish the necessary networks for disease prevention trials.

conclusionsAdvancing the field of IBD prediction and prevention will require a multifaceted approach, integrating biomarker discovery, understanding patient preferences, and establishing infrastructure for a collaborative network to support the practical implementation of IBD prevention strategies.

Indexed as

BiomarkersInflammatory Bowel DiseasesHumansRisk FactorsBiomarkers

Identifiers

PMID39403049
PMCPMC12148343

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.