Evidence map›Paper›PMID 39403003›Full record

ArticleVeterinary medicine and science2024

Antiviral Activity of Plant-Based Additives Against African Swine Fever Virus (ASFV) in Feed Ingredients.

Thi Ngoc Ha Lai, Thi Bich Ngoc Trinh, Thi Tam Than, Nguyen Tuan Anh Mai, Niku Moussavi Biuki, Bernhard Eckel, Viktor P L Eckel, Thi Lan Nguyen, Van Phan Le

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In one paragraph

Article in Veterinary medicine and science, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Thi Ngoc Ha LaiCollege of Veterinary Medicine, Vietnam National University of Agriculture (VNUA), Hanoi, Vietnam.
Thi Bich Ngoc TrinhCollege of Veterinary Medicine, Vietnam National University of Agriculture (VNUA), Hanoi, Vietnam.
Thi Tam ThanCollege of Veterinary Medicine, Vietnam National University of Agriculture (VNUA), Hanoi, Vietnam.
Nguyen Tuan Anh MaiCollege of Veterinary Medicine, Vietnam National University of Agriculture (VNUA), Hanoi, Vietnam.
Niku Moussavi BiukiDepartment of Microbiology and Infectious Disease, Dr. Eckel Animal Nutrition GmbH & Co. KG, Niederzissen, Germany.
Bernhard EckelDepartment of Microbiology and Infectious Disease, Dr. Eckel Animal Nutrition GmbH & Co. KG, Niederzissen, Germany.
Viktor P L EckelDepartment of Microbiology and Infectious Disease, Dr. Eckel Animal Nutrition GmbH & Co. KG, Niederzissen, Germany.
Thi Lan NguyenCollege of Veterinary Medicine, Vietnam National University of Agriculture (VNUA), Hanoi, Vietnam.
Van Phan LeCollege of Veterinary Medicine, Vietnam National University of Agriculture (VNUA), Hanoi, Vietnam.ORCID 0000-0003-0583-4111

Funding

the Vietnam National Project DTDL.CN-53/19
6 · The paper itself

Abstract

backgroundAfrican swine fever (ASF) is one of the deadliest swine diseases with haemorrhagic symptoms and a high mortality rate. Plant-derived additives are potential antiviral agents against viruses due to their environmental and user-friendly properties.

objectivesThis study aims to evaluate the efficacy of plant-based additives (Phyto.A04 and Phyto.B) compared to an organic acid blend (OAB) in inactivating ASF virus (ASFV) in cell culture and feed.

methodsASFV-spiked feed was treated with individual or combined additives such as OAB, Phyto.A04 and Phyto.B. The viability of ASFV after treatment of ASFV-spiked feed with additives was then confirmed by both methods, real-time PCR and cell culture.

resultsThe results of the in vitro test with cell cultures showed that all three additives (OAB, Phyto.A04 and Phyto.B) exerted a strong virucidal effect on ASFV in porcine alveolar macrophage cells. OAB at a concentration of 0.3% reduced the virus concentration from 4.48 log

conclusionsAll additives, OAB, Phyto.A04 and Phyto.B, were able to inactivate ASFV in a dose-dependent manner, as confirmed by cell culture and PCR methods. The combination of additives at different concentrations consistently improved the virucidal results.

Indexed as

African Swine FeverAnimal FeedAntiviral AgentsFood AdditivesPhytochemicalsAfrican Swine Fever VirusAnimalsGlycyrrhizaHordeumMacrophages, AlveolarPlant ExtractsReal-Time Polymerase Chain ReactionSus scrofaAntiviral AgentsFood AdditivesGlycyrrhiza glabra extractPhytochemicalsPlant Extractsantiviral activityASFASFVnatural productplant‐based additives

Identifiers

PMID39403003
PMCPMC11473970

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.