Evidence map›Paper›PMID 39402986›Full record

ArticleJournal of medicinal chemistry2024

Pharmacophore Establishment and Optimization of Saturated 1,6-Naphthyridine-Fused Quinazolinones that Inhibit Meningoencephalitis-Causing

Matthew S Lish, Jillian E M McKeon, Caroline M Palmentiero, Julia M Pomeroy, Colm P Roster, Ilia A Guzei, James C Morris, Jennifer E Golden

Abstract read
In one paragraph

Article in Journal of medicinal chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Matthew S LishDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Jillian E M McKeonEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States.
Caroline M PalmentieroEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States.
Julia M PomeroyDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.
Colm P RosterEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States.
Ilia A GuzeiMolecular Structure Laboratory, Department of Chemistry, University of Wisconsin-Madison, 1101 University Avenue, Madison, Wisconsin 53706, United States.ORCID 0000-0003-1976-7386
James C MorrisEukaryotic Pathogens Innovation Center, Department of Genetics and Biochemistry, Clemson University, Clemson, South Carolina 29634, United States.ORCID 0000-0003-2515-5714
Jennifer E GoldenDepartment of Chemistry, University of Wisconsin-Madison, Madison, Wisconsin 53706, United States.ORCID 0000-0002-6813-3710

Funding

UW COMPREHENSIVE CANCER CENTER SUPPORTP30CA014520 · NCI · UNIVERSITY OF WISCONSIN-MADISON · PI Justine Yang Bruce · 1985 to 2026
$142.6M
Regulation of Cryptosporidium DevelopmentP20GM146584 · NIGMS · CLEMSON UNIVERSITY · PI KERRY Scot SMITH · 2022 to 2026
$13.5M
Accelerated discovery of cell-active SARS-CoV-2 polymerase inhibitors via molecular dynamic guided screening and optimizationR21AI161232 · NIAID · UNIVERSITY OF WISCONSIN-MADISON · PI GOLDEN, JENNIFER E. · 2021 to 2021
$443k
Approaches for genetic manipulation of Naegleria fowleriR21AI175463 · NIAID · CLEMSON UNIVERSITY · PI MORRIS, JAMES CULVIN · 2023 to 2024
$419k
NCI NIH HHS P30 CA014520NIAID NIH HHS R21 AI161232NIAID NIH HHS R21 AI175463NIGMS NIH HHS P20 GM146584
6 · The paper itself

Abstract

Primary amoebic meningoencephalitis (PAM) is a human brain infection caused by

Indexed as

Naegleria fowleriQuinazolinonesAnimalsAntiprotozoal AgentsHumansMeningoencephalitisMicePharmacophoreStereoisomerismStructure-Activity RelationshipAntiprotozoal AgentsQuinazolinones

Identifiers

PMID39402986
PMCPMC11577639

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.