SynthesisCritical care (London, England)2024
A systematic review on the use of sevoflurane in the management of status asthmaticus in adults.
Synthesis in Critical care (London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
9 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Volatile sedation in critically ill adults undergoing mechanical ventilation: a meta-analysis of randomized controlled trials.Critical care (London, England) · 2025Pooled it
- Volatile anesthetic sedation in acute respiratory distress syndrome.Intensive care medicine · 2026Review
- Anesthetic Management of Eosinophilic Granulomatosis with Polyangiitis: A Narrative Review with an Illustrative Case in Cardiac Surgery.Journal of personalized medicine · 2026Review
- Lung protective characteristics of volatile anesthetic sedation.Critical care (London, England) · 2026Review
- Case Report: Tezepelumab as rescue therapy in near-fatal asthma requiring extracorporeal membrane oxygenation.Frontiers in immunology · 2026Article
- A multianalyte method for simultaneous evaluation of occupational exposure to anesthetic gases in urine samples from healthcare professionals.Frontiers in public health · 2026Article
- Management of refractory status asthmaticus with sevoflurane in the intensive care unit: Case reports.Respiratory medicine case reports · 2026Article
- Sevoflurane for refractory status asthmaticus: balancing bronchodilation with hepatic safety.Critical care (London, England) · 2025Article
- Is volatile sedation truly associated with increased mortality in mechanically ventilated critically ill adults compared to intravenous sedation? Moving beyond pairwise meta-analysis to individual agent assessment via bayesian network meta-analysis.Critical care (London, England) · 2025Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundTo conduct a systematic review looking into the use of sevoflurane in the management of status asthmaticus (SA) in adults.
methodsWe performed a systematic search on PubMed, EMBASE, and The Cochrane Library - CENTRAL through 23rd August 2023, restricting to studies reported in English. We included studies reporting use of sevoflurane in asthmatics beyond its use as an anaesthetic agent in surgeries i.e. in the emergency department (ED) and critical care setting, and focused on patient's clinical parameters, ventilation pressures and weaning of invasive ventilation.
resultsA total of 13 publications fulfilled the inclusion criteria, comprising of 18 cases. All publications were of case reports/ series and conference abstracts, and no randomised trials were available. Most patients required intubation despite best medical management before sevoflurane administration, and high airway pressures and respiratory acidosis were apparent. There was significant heterogeneity regarding severity of asthma, treatment instituted, and the delivery, duration and concentration of sevoflurane administered. Many of the studies also did not quantify the changes in parameters pre- and post-sevoflurane. Sixteen patients experienced improvements in clinical status with sevoflurane administration-one required escalation to extracorporeal membrane oxygenation (ECMO), and another did not survive.
conclusionThe systematic review suggests sevoflurane can be a valuable treatment option in SA. As these cases are rare and heterogenous, further prospective case series are needed to support this.
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