Evidence map›Paper›PMID 39402583›Full record

Trial reportJournal of orthopaedic surgery and research2024

Evaluating the impact of platelet-rich plasma injection in spinal endoscopic nucleotomy on MRI pfirrmann grading and clinical outcomes in lumbar disc herniation.

Hairu Qi, Zhimin Zhou, Gaoxiang Li, Yonggen Huang, Shujin Chen, Bao Liu

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Journal of orthopaedic surgery and research, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Article
  5. Article
  6. Lumbar Disc Herniation: What's New in Surgical Treatment.Revista brasileira de ortopedia · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Hairu Qi *Department of Orthopaedics, Zhongshan Torch Development Zone People's Hospital, Zhongshan, 528437, Guangdong, China. qhr10363@163.com.
Zhimin Zhou *Department of General surgery, Zhongshan Torch Development Zone People's Hospital, Zhongshan, 528437, Guangdong, China.
Gaoxiang LiDepartment of Orthopaedics, Zhongshan Torch Development Zone People's Hospital, Zhongshan, 528437, Guangdong, China.
Yonggen HuangDepartment of Orthopaedics, Zhongshan Torch Development Zone People's Hospital, Zhongshan, 528437, Guangdong, China.
Shujin ChenDepartment of Orthopaedics, Zhongshan Torch Development Zone People's Hospital, Zhongshan, 528437, Guangdong, China.
Bao LiuDepartment of Orthopaedics, Zhongshan Torch Development Zone People's Hospital, Zhongshan, 528437, Guangdong, China. LB20100801@126.com.

Funding

Zhongshan city social welfare and basic research project 2022B1150
6 · The paper itself

Abstract

backgroundThis study investigates the clinical efficacy and safety of percutaneous endoscopic nucleotomy combined with platelet-rich plasma (PRP) injection in treating lumbar disc herniation (LDH) in young and middle-aged adults.

methodsFrom April 2022 to September 2023, 60 patients diagnosed with LDH were randomly divided into two groups (n = 30/group). The observation group underwent percutaneous endoscopic nucleotomy combined with autologous PRP gel injection into the disc, while the control group underwent percutaneous endoscopic nucleotomy alone. Visual Analogue Scale (VAS) scores and Oswestry Disability Index (ODI) scores were recorded preoperatively and at three time points postoperatively: three days, three months, and six months. The modified Macnab criteria were employed to evaluate efficacy at the final follow-up. Additionally, MRI Pfirrmann grading of the operated disc segment and potential complications were assessed both preoperatively and at the final follow-up.

resultsAll patients were followed for a minimum of six months. VAS and ODI scores at all postoperative time points (three days, three months, and six months) exhibited significant differences compared to preoperative scores in both groups (P < 0.05). Notably, a significant difference was observed in VAS and ODI scores between the two groups at three days postoperatively (P < 0.05). Preoperative MRI Pfirrmann grading indicated no significant difference between groups (P = 0.669). However, at the final follow-up, the observation group demonstrated superior recovery compared to the control group (P = 0.013). The modified Macnab criteria revealed no significant difference in the rates of excellent and good outcomes between the observation group (96.67%) and the control group (93.33%) (P > 0.05). Furthermore, no patients experienced complications such as dural tears, nerve root injury, infection, or hematoma.

conclusionThe combination of percutaneous endoscopic nucleotomy and PRP injection could be a safe and effective treatment for LDH in young and middle-aged adults to promote disc repair following endoscopic procedures.

Indexed as

EndoscopyIntervertebral Disc DisplacementLumbar VertebraeMagnetic Resonance ImagingPlatelet-Rich PlasmaAdultDiskectomy, PercutaneousFemaleFollow-Up StudiesHumansMaleMiddle AgedTreatment OutcomeDisability evaluationLumbar disc herniationMicrodiscectomyPain measurementPlatelet-rich plasmaQuality of lifeSpinal endoscopyTreatment outcomes

Identifiers

PMID39402583
PMCPMC11476116

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.