Evidence map›Paper›PMID 39402576›Full record

ReviewStem cell research & therapy2024

Extracellular vesicles as therapeutic tools in regenerative dentistry.

Evelyn Jingwen Xia, Shasha Zou, Xiu Zhao, Wei Liu, Yang Zhang, Irene Shuping Zhao

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Stem cell research & therapy, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Evelyn Jingwen Xia *School of Dentistry, Shenzhen University Medical School, 1088 Xueyuan Ave, Shenzhen, 518015, China.
Shasha Zou *Longgang Center for Chronic Disease Control, Shenzhen, 518172, China.
Xiu ZhaoDepartment of Stomatology, Shenzhen University General Hospital, Shenzhen, 518015, China.
Wei LiuDepartment of Stomatology, Shenzhen University General Hospital, Shenzhen, 518015, China.
Yang ZhangSchool of Dentistry, Shenzhen University Medical School, 1088 Xueyuan Ave, Shenzhen, 518015, China. yang.zhang@szu.edu.cn.ORCID 0000-0002-7864-1452
Irene Shuping ZhaoSchool of Dentistry, Shenzhen University Medical School, 1088 Xueyuan Ave, Shenzhen, 518015, China. zhao110@szu.edu.cn.

Funding

Medicine Plus Program of Shenzhen University Medicine Plus Program of Shenzhen UniversityScience Technology and Innovation Committee of Shenzhen Municipality 20220810163811002Science Technology and Innovation Committee of Shenzhen Municipality 20220810173216001Shenzhen Medical Academy of Research and Translation A2303069
6 · The paper itself

Abstract

Dental and maxillofacial diseases are always accompanied by complicated hard and soft tissue defects, involving bone, teeth, blood vessels and nerves, which are difficult to repair and severely affect the life quality of patients. Recently, extracellular vesicles (EVs) secreted by all types of cells and extracted from body fluids have gained more attention as potential solutions for tissue regeneration due to their special physiological characteristics and intrinsic signaling molecules. Compared to stem cells, EVs present lower immunogenicity and tumorigenicity, cause fewer ethical problems, and have higher stability. Thus, EV therapy may have a broad clinical application in regenerative dentistry. Herein, we reviewed the currently available literature regarding the functional roles of EVs in oral and maxillofacial tissue regeneration, including in maxilla and mandible bone, periodontal tissues, temporomandibular joint cartilage, dental hard tissues, peripheral nerves and soft tissues. We also summarized the underlying mechanisms of actions of EVs and their delivery strategies for dental tissue regeneration. This review would provide helpful guidelines and valuable insights into the emerging potential of EVs in future research and clinical applications in regenerative dentistry.

Indexed as

Extracellular VesiclesRegenerative MedicineAnimalsDentistryHumansRegenerationDental tissueDentistryExosomesExtracellular vesiclesTissue regeneration

Identifiers

PMID39402576
PMCPMC11476107

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.