Evidence map›Paper›PMID 39402512›Full record

ArticleBMC biotechnology2024

Optimization of culture conditions for HBV-specific T cell expansion in vitro from chronically infected patients.

Li Wang, Hongjiao Chen, Yuanqi Yang, Ying Huang, Weixian Chen, Di Mu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in BMC biotechnology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Li Wang *Department of Laboratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Hongjiao Chen *Department of Laboratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Yuanqi YangDepartment of Laboratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Ying HuangDepartment of Laboratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China.
Weixian ChenDepartment of Laboratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. 300801@hospital.cqmu.edu.cn.
Di MuDepartment of Laboratory Medicine, The Second Affiliated Hospital, Chongqing Medical University, Chongqing, China. 303921@hospital.cqmu.edu.cn.

Funding

China Postdoctoral Science Foundation 2023MD734123Kuanren Talents Program of the Second Affiliated Hospital of Chongqing Medical University Kryc-Yq-2210National Natural Science Foundation of China 82102376
6 · The paper itself

Abstract

backgroundHepatitis B virus (HBV) clearance depends on an effective adaptive immune response, especially HBV-specific T cell-mediated cellular immunity; however, it is difficult to produce enough HBV-specific T cells effectively.

resultsIn this work, we investigated the proportions of stimulated cells, serum, and culture media as the three primary factors to determine the most effective procedure and applied it to HLA-A2 (+) people. In parallel, we also examined the correlation between clinical parameters and HBV-specific immunity. Concerning amplification efficiency, 4 × 10

conclusionsWe confirm that stimulating 4 × 10

Indexed as

Cell Culture TechniquesHepatitis B, ChronicHepatitis B virusAdultCD8-Positive T-LymphocytesCell ProliferationCells, CulturedCulture MediaFemaleHepatitis B Surface AntigensHLA-A2 AntigenHumansMaleMiddle AgedT-LymphocytesCulture MediaHepatitis B Surface AntigensHLA-A2 AntigenCD8 + T cellsExpansionHepatitis B virus

Identifiers

PMID39402512
PMCPMC11476462

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.