ArticleBMC genomics2024
Developmental and validation of a novel small and high-efficient panel of microhaplotypes for forensic genetics by the next generation sequencing.
Article in BMC genomics, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Applicability of imprinted DIP-SNP markers in DNA mixture analysis: a pilot study.International journal of legal medicine · 2026Article
- Moderate-density SNPs combined with machine learning method driven kinship identification and East Asian subpopulations discrimination analysis.International journal of legal medicine · 2026Article
- Development and Evaluation of a Novel Microhaplotype Panel for DNA Mixture and Kinship Analysis.Electrophoresis · 2026Article
- Review
- Screening of microhaplotypes for paternity testing from low-recombination regions in the human genome.BMC genomics · 2026Article
- [Forensic performance and genetic background analyses of Guizhou Chuanqing population using a self-constructed microhaplotype panel].Nan fang yi ke da xue xue bao = Journal of Southern Medical University · 2025Article
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Authors and funding
17 authors.
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Abstract
backgroundIn the domain of forensic science, the application of kinship identification and mixture deconvolution techniques are of critical importance, providing robust scientific evidence for the resolution of complex cases. Microhaplotypes, as the emerging class of genetic markers, have been widely studied in forensics due to their high polymorphisms and excellent stability. RESULTS AND DISCUSSION: In this research, a novel and high-efficient panel integrating 33 microhaplotype loci along with a sex-determining locus was developed by the next generation sequencing technology. In addition, we also assessed its forensic utility and delved into its capacity for kinship analysis and mixture deconvolution. The average effective number of alleles (Ae) of the 33 microhaplotype loci in the Guizhou Han population was 6.06, and the Ae values of 30 loci were greater than 5. The cumulative power of discrimination and cumulative power of exclusion values of the novel panel in the Guizhou Han population were 1-5.6 × 10
conclusionsIn summary, we have developed a small and high-efficient panel for forensic genetics, which could provide novel insights into forensic complex kinships testing and mixture deconvolution.
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