Evidence map›Paper›PMID 39402391›Full record

ArticleInternational journal of clinical oncology2024

Lateral node metastasis in low rectal cancer as a hallmark to predict recurrence patterns.

Eiji Shinto, Hideyuki Ike, Masaaki Ito, Keiichi Takahashi, Masayuki Ohue, Yukihide Kanemitsu, Takeshi Suto, Tetsushi Kinugasa, Jun Watanabe, Jin-Ichi Hida and 7 more

Abstract read
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In one paragraph

Article in International journal of clinical oncology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Eiji ShintoDepartment of Surgery, Self-Defense Forces Central Hospital, 1-2-24 Ikejiri, Setagaya, Tokyo, 154-8532, Japan. eiji-c@zf6.so-net.ne.jp.ORCID http://orcid.org/0000-0002-1046-1789
Hideyuki IkeDepartment of Surgery, JCHO Yokohama Hodogaya Central Hospital, 43-1 Kamadai, Hodogaya, Yokohama, Kanagawa, Japan.
Masaaki ItoDepartment of Colorectal Surgery, National Cancer Center Hospital East, 6-5-1 Kashiwanoha, Kashiwa, Chiba, Japan.
Keiichi TakahashiDepartment of Surgery, Tokyo Metropolitan Health and Hospitals Corporation Ohkubo Hospital, 2-44-1 Kabuki, Shinjyuku, Tokyo, Japan.
Masayuki OhueDepartment of Gastroenterological Surgery, Osaka International Cancer Institute, 3-1-69, Otemae, Chuo, Osaka, Japan.
Yukihide KanemitsuDepartment of Colorectal Surgery, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo, Tokyo, Japan.
Takeshi SutoDepartment of Gastroenterological Surgery, Yamagata Prefectural Central Hospital, Aoyagi, Yamagata, 1800, Japan.
Tetsushi KinugasaFukuokamitsuki Hospital, 1-2-1 Befu, Jonan, Fukuoka, Japan.
Jun WatanabeDepartment of Colorectal Surgery, Kansai Medical University, 5-1 Shinmachi 2 Chome, Hirakata, Osaka, Japan.
Jin-Ichi HidaDepartment of Surgery, Kindai University Nara Hospital, Otoda, Ikoma, Nara, 1248-1, Japan.
Michio ItabashiSaiseikai Kazo Hospital, Kamitakayanagi, Kazo, Saitama, 1680, Japan.
Heita OzawaDepartment of Colorectal Surgery, Tochigi Cancer Center, 4-9-13 Yohnan, Utsunomiya, Tochigi, Japan.
Hiroaki NozawaDepartment of Surgical Oncology, The University of Tokyo, 7-3-1 Hongo, Bunkyo, Tokyo, Japan.
Yojiro HashiguchiDepartment of Surgery, Omori Red Cross Hospital, 4-30-1 Chuo, Ota, Tokyo, Japan.
Kazuo HaseDepartment of Surgery, National Defense Medical College, 3-2 Namiki, Tokorozawa, Saitama, Japan.
Kenichi SugiharaTokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo, Tokyo, Japan.
Yoichi AjiokaDivision of Molecular and Diagnostic Pathology, Graduate School of Medical and Dental Sciences, Niigata University, 757 Ichibancho, Asahimachi-dori, Chuo Ward, Niigata, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundLateral node metastasis confers a poor prognosis in rectal cancer. Several multidisciplinary treatments have been proposed with favorable outcomes. However, appropriate neoadjuvant/adjuvant treatments or follow-up plans based on information about the probable recurrence site have not been specified. We aimed to clarify the distinctive features of recurrence patterns for lateral node-positive low rectal cancer according to the lateral and mesorectal lymph node status.

methodsWe retrospectively analyzed 508 patients with stage III low rectal cancer who underwent lateral node dissection. We investigated the impact of lateral and mesorectal lymph node status on site-specific recurrence rates and patient survival.

resultsAnalyses for relapse-free survival revealed the prognostic impact of lateral node positivity in stage III low rectal cancer (p < 0.0001). Lateral node-positive patients exhibited higher risk of overall recurrence, local recurrence, and recurrence in extra-regional nodes than lateral node-negative patients (p < 0.0001, p = 0.001, and p < 0.0001, respectively). However, lateral node positivity was not statistically associated with a hematogenous recurrence rate. In lateral node-positive patients, both tumor-node-metastasis (TNM)-N status and number of lateral nodes involved were revealed as significant prognostic factors (p < 0.0001, both). In addition, the number of lateral nodes involved could be a discriminatory indicator of probabilities of local recurrence and recurrence in extra-regional nodes (p = 0.02, and p < 0.0001, respectively).

conclusionsLateral node-positive low rectal cancer exhibits higher local recurrence and extra-regional node recurrence rates that correlate with the number of lateral nodes involved.

Indexed as

Lymphatic MetastasisLymph NodesNeoplasm Recurrence, LocalRectal NeoplasmsAdultAgedAged, 80 and overDisease-Free SurvivalFemaleHumansLymph Node ExcisionMaleMiddle AgedNeoplasm StagingPrognosisRetrospective StudiesLateral node metastasisLocal recurrencePrognosisRecurrence in extra-regional nodesStage III low rectal cancer

Identifiers

PMID39402391

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.