Evidence map›Paper›PMID 39402275›Full record

ArticleCommunications biology2024

Golgi-localized Ring Finger Protein 121 is necessary for MYCN-driven neuroblastoma tumorigenesis.

Belamy B Cheung, Ritu Mittra, Jayne Murray, Qian Wang, Janith A Seneviratne, Mukesh Raipuria, Iris Poh Ling Wong, David Restuccia, Andrew Gifford, Alice Salib and 23 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Communications biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

33 authors.

Belamy B Cheung *Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia. bcheung@ccia.unsw.edu.au.ORCID 0000-0001-8784-860X
Ritu Mittra *Children's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.
Jayne MurrayChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.
Qian WangChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.ORCID 0000-0002-6514-3470
Janith A SeneviratneChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.ORCID 0000-0003-0413-5829
Mukesh RaipuriaChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.
Iris Poh Ling WongChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.
David RestucciaChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.
Andrew GiffordChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.ORCID 0000-0002-4092-2347
Alice SalibChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.
Selina SuttonChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.
Libby HuangChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.ORCID 0000-0001-7398-0570
Parisa Vahidi FerdowsiChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.
Joanna TsangChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.
Eric SekyereChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.
Chelsea MayohChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.ORCID 0000-0002-6398-3046
Lin LuoInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0001-5556-7096
Darren L BrownInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.
Jennifer L StowInstitute for Molecular Bioscience, University of Queensland, Brisbane, QLD, Australia.ORCID 0000-0002-5409-9101
Shizhen ZhuDepartment of Biochemistry and Molecular Biology, Cancer Center and Center for Individualized Medicine, Mayo Clinic, Rochester, MN, USA.ORCID 0000-0002-2929-3279
Richard J YoungPeter MacCallum Cancer Centre, Melbourne, Australia.
Benjamin J SolomonPeter MacCallum Cancer Centre, Melbourne, Australia.ORCID 0000-0003-3059-5730
Stephane ChappazAnatomy & Developmental Biology, Monash University, Melbourne, Australia.ORCID 0000-0003-0574-7544
Benjamin KileFaculty of Health and Medical Sciences at the University of Adelaide, Adelaide, Australia.
Andrew KuehBlood Cells and Blood Cancer Division, Walter and Eliza Hall Institute, Melbourne, Australia.
Marco J HeroldBlood Cells and Blood Cancer Division, Walter and Eliza Hall Institute, Melbourne, Australia.
Douglas J HiltonBlood Cells and Blood Cancer Division, Walter and Eliza Hall Institute, Melbourne, Australia.
Tao LiuChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.ORCID 0000-0001-6244-7316
Murray D NorrisChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.
Michelle HaberChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.
Daniel R CarterChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia.ORCID 0000-0002-8464-238X
Michael W ParkerACRF Facility for Innovative Cancer Drug Discovery and Department of Biochemistry and Pharmacology, Bio21 Molecular Science and Biotechnology Institute, The University of Melbourne, Parkville, Victoria, Australia.ORCID 0000-0002-3101-1138
Glenn M MarshallChildren's Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW Sydney, Sydney, Australia. glenn.marshall@health.nsw.gov.au.ORCID 0000-0002-2503-0762

Funding

Interplay between low levels of GAS7 expression and MYCN overexpression and its impact on neuroblastoma metastasisR01CA240323 · NCI · MAYO CLINIC ROCHESTER · PI ZHU, SHIZHEN · 2020 to 2024
$1.8M
Cancer Council NSW (Cancer Council New South Wales) RG21-08Cancer Council NSW (Cancer Council New South Wales) RG214491Department of Health | National Health and Medical Research Council (NHMRC) APP1125171NCI NIH HHS R01 CA240323
6 · The paper itself

Abstract

MYCN amplification predicts poor prognosis in childhood neuroblastoma. To identify MYCN oncogenic signal dependencies we performed N-ethyl-N-nitrosourea (ENU) mutagenesis on the germline of neuroblastoma-prone TH-MYCN transgenic mice to generate founders which had lost tumorigenesis. Sequencing of the mutant mouse genomes identified the Ring Finger Protein 121 (RNF121

Indexed as

NeuroblastomaN-Myc Proto-Oncogene ProteinAnimalsCarcinogenesisCell Line, TumorGene Expression Regulation, NeoplasticGolgi ApparatusHumansMiceMice, TransgenicMYCN protein, humanN-Myc Proto-Oncogene Protein

Identifiers

PMID39402275
PMCPMC11473750

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.