Associations between elevated uric acid and brain imaging abnormalities in pediatric patients with methylmalonic acidemia under 5 years of age.

Mengmeng Du, Shengnan Wu, Yongxing Chen, Shuxian Yuan, Shijie Dong, Huizhen Wang, Haiyan Wei, Changlian Zhu

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Article in Scientific reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1 citing paper in PubMed.

Methylmalonic acid: a new target for Hadamard-edited MRS.bioRxiv : the preprint server for biology · 2026
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5 · Who and what money

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8 authors.

Mengmeng DuHenan Pediatric Clinical Research Center and Key Laboratory of Child Brain Injury, Institute of Neuroscience, Third Affiliated Hospital of Zhengzhou University, No. 7, Kangfuqian Street, Erqi District, Zhengzhou, China.

Shengnan WuDepartment of Endocrinology, Genetics and Metabolism, Henan Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.

Yongxing ChenDepartment of Endocrinology, Genetics and Metabolism, Henan Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.

Shuxian YuanDepartment of Endocrinology, Genetics and Metabolism, Henan Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.

Shijie DongDepartment of Radiology, Henan Children's Hospital, Zhengzhou, China.

Huizhen WangDepartment of Endocrinology, Genetics and Metabolism, Henan Children's Hospital, Children's Hospital Affiliated to Zhengzhou University, Zhengzhou, China.

Haiyan WeiHenan Pediatric Clinical Research Center and Key Laboratory of Child Brain Injury, Institute of Neuroscience, Third Affiliated Hospital of Zhengzhou University, No. 7, Kangfuqian Street, Erqi District, Zhengzhou, China. Haiyanwei2009@163.com.

Changlian ZhuHenan Pediatric Clinical Research Center and Key Laboratory of Child Brain Injury, Institute of Neuroscience, Third Affiliated Hospital of Zhengzhou University, No. 7, Kangfuqian Street, Erqi District, Zhengzhou, China. changlian.zhu@neuro.gu.se.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Methylmalonic acidemia (MMA) is the most common inborn organic acidemia, presenting multisystemic complications. Uric acid may have neurotoxic or neuroprotective effects due to its antioxidant or pro-inflammatory properties; however, its role in MMA brain injury remains unclear. We examined the correlation between the serum uric acid levels and brain imaging features of MMA. Data were collected from a cross-sectional study of 216 patients with MMA and 216 healthy matched controls aged 0-5 years in China. Serum uric acid levels were measured, and magnetic resonance imaging and computed tomography findings were retrieved from hospital records. Overall, 74.1% patients had brain abnormalities. Patients in the MMA group with abnormal brain imaging had higher serum uric acid levels than those in the MMA normal brain imaging and control groups. The area under the curve of serum uric acid was 0.74, 0.91, and 0.93 for MMA diagnosis with abnormal brain images, basal ganglia changes, and globus pallidus changes, respectively. Higher serum uric acid levels were independently associated with abnormal brain images. Children aged < 5 years with abnormal brain images in MMA exhibit elevated serum uric acid levels, serving as an effective auxiliary diagnostic indicator and independent risk factor for brain tissue injury.

Indexed as

Amino Acid Metabolism, Inborn ErrorsBrainMagnetic Resonance ImagingUric AcidCase-Control StudiesChild, PreschoolChinaCross-Sectional StudiesFemaleHumansInfantInfant, NewbornMaleTomography, X-Ray ComputedUric AcidBrain imageBrain structural injuryChildrenMethylmalonic academiaUric acid

Identifiers

PMID39402119

DOI10.1016/j.cca.2011.01.011

PMCPMC11473513

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