Evidence map›Paper›PMID 39402059›Full record

Articlenpj aging2024

p53 dependence of senescence markers p21v1 and p21v2 in aging and acute injury.

Parmita Kar, Ashok Sivasailam, Rupa Lavarti, Lun Cai, Muthusamy Thangaraju, Emma Nguyen, Bhavishya Mundluru, Raghavan Pillai Raju

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in npj aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Parmita KarDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0000-0001-9909-4251
Ashok Sivasailam *Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Rupa Lavarti *Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Lun Cai *Department of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Muthusamy ThangarajuDepartment of Biochemistry and Molecular Biology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Emma NguyenDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.ORCID http://orcid.org/0009-0002-9159-4870
Bhavishya MundluruDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA.
Raghavan Pillai RajuDepartment of Pharmacology and Toxicology, Medical College of Georgia, Augusta University, Augusta, GA, USA. RRaju@augusta.edu.

Funding

Reparative effect of juvenile factors in aging and injuryR01AG073338 · NIA · AUGUSTA UNIVERSITY · PI Raghavan Pillai Raju · 2022 to 2026
$2.8M
Metabolic alterations in hemorrhagic shockR01GM122059 · NIGMS · AUGUSTA UNIVERSITY · PI RAJU, RAGHAVAN PILLAI · 2017 to 2020
$1.2M
NIA NIH HHS R01 AG073338NIGMS NIH HHS R01 GM122059U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01AG073338U.S. Department of Health & Human Services | National Institutes of Health (NIH) R01GM122059
6 · The paper itself

Abstract

The senescence phenotype is heterogeneous, as observed by the context-dependent differential expression of senescence markers. Here, we provide evidence to demonstrate an inverse relationship in the expression pattern of the two murine variants of p21 (p21v1, and p21v2) in aging and hemorrhagic shock. While an upregulation of p21v1 was observed following hemorrhagic shock injury, p21v2 was upregulated in the aged mouse. We further show that the p21v1 response is, at least, partially independent of p53.

Identifiers

PMID39402059
PMCPMC11473800

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.