Evidence map›Paper›PMID 39401913›Full record

ArticleInternal medicine (Tokyo, Japan)2025

Hamman Syndrome Caused by a Sodium Glucose Cotransporter 2 Inhibitor in an Elderly Patient with Diabetes Which Mimicked of Boerhaave Syndrome.

Kai Korekawa, Hiroaki Mitsugashira, Yoshiyuki Yashima, Takeshi Asakura

Abstract readCase Reports
In one paragraph

Article in Internal medicine (Tokyo, Japan), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Kai KorekawaDepartment of Gastroenterology, Kesen-numa City Hospital, Japan.
Hiroaki MitsugashiraDepartment of Surgery, Kesen-numa City Hospital, Japan.
Yoshiyuki YashimaDepartment of Surgery, Kesen-numa City Hospital, Japan.
Takeshi AsakuraDepartment of Surgery, Kesen-numa City Hospital, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 70-year-old man with diabetes was treated with a sodium glucose cotransporter 2 (SGLT2) inhibitor. He developed vomiting and epigastric pain and was diagnosed with diabetic ketoacidosis (DKA). Computed tomography (CT) revealed mediastinal emphysema. As Boerhaave syndrome could not be ruled out, treatment was initiated in parallel with DKA treatment. After the DKA healed, the mediastinal emphysema disappeared. DKA combined with mediastinal emphysema is known as Hamman syndrome. There have been no reports of Hamman syndrome in elderly patients with diabetes caused by SGLT2 inhibitors. His symptoms mimicked the course of Boerhaave syndrome, and such cases have a high risk of misdiagnosis.

Indexed as

Diabetes Mellitus, Type 2Diabetic KetoacidosisEsophageal PerforationMediastinal EmphysemaSodium-Glucose Transporter 2 InhibitorsAgedDiagnosis, DifferentialEsophageal DiseasesHumansMaleMediastinal DiseasesRupture, SpontaneousSpontaneous PerforationTomography, X-Ray ComputedSodium-Glucose Transporter 2 InhibitorsBoerhaave syndromediabetic ketoacidosisHamman syndromemediastinal emphysemasodium glucose cotransporter 2 inhibitors

Identifiers

PMID39401913
PMCPMC12120236

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.