Evidence map›Paper›PMID 39401858›Full record

ArticleThe European respiratory journal2025

Ansa cervicalis stimulation effects on upper airway patency: a structure-based analysis.

Yike Li, Alan R Schwartz, David Zealear, Matthew S Shotwell, Megan E Hall, Christopher J Lindsell, Holly A Budnick, Silvana Bellotto, David T Kent

Abstract read
In one paragraph

Article in The European respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. [Dynamic assessment of upper airway in obstructive sleep apnea patients with a focus on drug-induced sleep endoscopy].Lin chuang er bi yan hou tou jing wai ke za zhi = Journal of clinical otorhinolaryngology head and neck surgery · 2026
    Review
  5. Review
  6. Review
  7. Intraoperative Identification and Stimulation of the Ansa Cervicalis Nerve Plexus.Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery · 2026
    Article
  8. Review
  9. Review
  10. Integrative treatment of obstructive sleep apnea: principles and practice.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2025
    Review
  11. Article
  12. Article
  13. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

9 authors.

Yike LiDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0001-8465-130X
Alan R SchwartzDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0001-9222-3751
David ZealearDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0001-9363-8377
Matthew S ShotwellDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0002-1480-0637
Megan E HallDepartment of Biostatistics, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0009-0003-9796-2053
Christopher J LindsellThe Duke Clinical Research Institute, Duke University, Durham, NC, USA.ORCID https://orcid.org/0000-0002-3297-2811
Holly A BudnickDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA.ORCID https://orcid.org/0000-0003-1215-8289
Silvana BellottoHospital Vila Nova Star, São Paulo, Brazil.ORCID https://orcid.org/0000-0001-5562-7191
David T KentDepartment of Otolaryngology - Head and Neck Surgery, Vanderbilt University Medical Center, Nashville, TN, USA david.kent@vumc.org.ORCID https://orcid.org/0000-0001-8183-5269

Funding

The Effect of Ansa Cervicalis Neurostimulation on Airway Patency in Obstructive Sleep ApneaR01HL161635 · NHLBI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI David T. Kent · 2022 to 2026
$3.9M
NHLBI NIH HHS R01 HL161635
6 · The paper itself

Abstract

rationaleAnsa cervicalis stimulation (ACS) of the infrahyoid muscles has been proposed as a neurostimulation therapy for obstructive sleep apnoea (OSA). ACS stabilises the pharynx by pulling it caudally, but its specific effects on flow limitation caused by palatal, oropharyngeal lateral wall, tongue base, or epiglottis collapse remains unclear.

objectivesTo quantify the effect of ACS on collapsibility of different pharyngeal flow-limiting structures.

methodsParticipants with OSA underwent bilateral ACS during drug-induced sleep endoscopy. Maximum inspiratory airflow was assessed over a range of positive airway pressures while ACS was applied. The flow-limiting structure for each breath was classified based on manometric and endoscopic findings and a linear mixed-effects model characterised their response to ACS. The influence of patient characteristics was explored with univariate models. MEASUREMENTS AND MAIN

results41 participants yielded 1761 breaths for analysis. On average, bilateral ACS decreased the observed pharyngeal critical closing (

conclusionsBilateral ACS decreased collapsibility of all airway flow-limiting structures. ACS generally had greater effects on palatal, oropharyngeal lateral wall and epiglottic collapse than the tongue base.

Indexed as

Electric Stimulation TherapyPharynxSleep Apnea, ObstructiveAdultAgedEndoscopyEpiglottisFemaleHumansMaleMiddle AgedPolysomnographyTongue

Identifiers

PMID39401858
PMCPMC11740831

What OpenQuestion holds

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LicenceCC BY-NC
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.