Evidence map›Paper›PMID 39401853›Full record

ArticleThe European respiratory journal2025

Skewed adaptive immune responses are involved in alpha-1 antitrypsin deficiency emphysema.

Joselyn Rojas-Quintero, Scott A Ochsner, Hyun-Sung Lee, Christine Cong, Alan Waich Cohen, Adrianne S Colborg, Konstantin Tsoyi, Maria C Basil, Edward Cantu, Ivan O Rosas and 5 more

Abstract readLetter
In one paragraph

Article in The European respiratory journal, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed.

  1. Article
  2. Review
  3. Article
  4. Lung NR3C1Communications biology · 2025
    Article
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

15 authors.

Joselyn Rojas-QuinteroPulmonary Division, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Scott A OchsnerDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.
Hyun-Sung LeeSystems Onco-Immunology Laboratory, David J. Sugarbaker Division of Thoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, TX, USA.
Christine CongPulmonary Division, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Alan Waich CohenPulmonary Division, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Adrianne S ColborgDepartment of Pulmonary Pediatrics, Texas Children's Hospital, Houston, TX, USA.
Konstantin TsoyiPulmonary Division, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Maria C BasilPenn-CHOP Lung Biology Institute, University of Pennsylvania, Philadelphia, PA, USA.ORCID https://orcid.org/0000-0003-4716-1285
Edward CantuDivision of Cardiovascular Surgery, Department of Surgery, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ivan O RosasPulmonary Division, Department of Medicine, Baylor College of Medicine, Houston, TX, USA.
Neil J McKennaDepartment of Molecular and Cellular Biology, Baylor College of Medicine, Houston, TX, USA.ORCID https://orcid.org/0000-0001-6689-0104
Raúl San-José EstéparApplied Chest Imaging Laboratory, Department of Radiology, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, USA.ORCID https://orcid.org/0000-0002-3677-1996
Igor BarjaktarevicPulmonary and Critical Care Medicine, UCLA, Los Angeles, CA, USA.
Andrew A WilsonCenter for Regenerative Medicine (CreM) of Boston University and Boston Medical Center, Boston, MA, USA.
Francesca PolverinoPulmonary Division, Department of Medicine, Baylor College of Medicine, Houston, TX, USA fpolverino@copdnet.org.

Funding

B cell-adaptive Immune Profile in Emphysema-predominant COPDR01HL149744 · NHLBI · UNIVERSITY OF ARIZONA · PI POLVERINO, FRANCESCA · 2020 to 2024
$3.4M
Protective effects of metformin against cigarette smoke-induced lung pathologies via regulation of fatty acids metabolismR01HL171622 · NHLBI · BAYLOR COLLEGE OF MEDICINE · PI Francesca Polverino · 2024 to 2026
$2.2M
NHLBI NIH HHS R01 HL149744NHLBI NIH HHS R01 HL171622
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Identifiers

PMID39401853
PMCPMC11695135

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.