Evidence map›Paper›PMID 39401429›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Wireless, Programmable, and Refillable Hydrogel Bioelectronics for Enhanced Diabetic Wound Healing.

Ningjie Du, Yunlong Fan, Yunting Zhang, Hao Huang, Yidan Lyu, Ruisi Cai, Yuqi Zhang, Tianyuan Zhang, Yixin Guan, Kewang Nan

Abstract read
In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Ningjie DuCollege of Chemical and Biological Engineering, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
Yunlong FanCollege of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
Yunting ZhangCollege of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
Hao HuangCollege of Chemical and Biological Engineering, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
Yidan LyuCollege of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
Ruisi CaiCollege of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
Yuqi ZhangCollege of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
Tianyuan ZhangCollege of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
Yixin GuanCollege of Chemical and Biological Engineering, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.
Kewang NanCollege of Pharmaceutical Sciences, Zhejiang University, 866 Yuhangtang Road, Hangzhou, 310058, China.ORCID 0000-0002-2745-0656

Funding

Key Technologies Research and Development Program 2022YFA1207000National Natural Science Foundation of China 21878262
6 · The paper itself

Abstract

Diabetic wounds, characterized by complex pathogenesis and high infection rates, pose significant challenges in treatment due to prolonged recovery times and high recurrence rates, often leading to severe complications such as amputation and death. Traditional dry dressing treatments fail to address the unique microenvironment of diabetic wounds and tend to cause secondary damage due to frequent replacement. In this study, an electronic-embedding, drug-loading hydrogel bioelectronics is reported for accelerating diabetic wound healing using a combination of programmable pharmaceutical and electrostimulative approaches. Encapsulated in stretchable and biocompatible materials, this device is capable of multiple drug refilling and accelerated drug release modulated by on-board electronics. In vivo experiments on diabetic model rats confirm the device's effectiveness in promoting wound healing. This innovative approach implies the potential for improving diabetic wound management using a combination of physical, material, and pharmaceutical interventions.

Indexed as

Diabetes Mellitus, ExperimentalHydrogelsWound HealingAnimalsBiocompatible MaterialsDisease Models, AnimalMaleRatsRats, Sprague-DawleyWireless TechnologyBiocompatible MaterialsHydrogelsdiabetic wound healingdrug deliveryelectrostimulationhydrogel bioelectronicswireless wearable electronics

Identifiers

PMID39401429
PMCPMC11615824

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.