Evidence map›Paper›PMID 39401410›Full record

ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2024

Precise Control of Intracellular Trafficking and Receptor-Mediated Endocytosis in Living Cells and Behaving Animals.

Shiau-Chi Chen, Neng-Jie Zeng, Grace Y Liu, Hsien-Chu Wang, Tzu-Ying Lin, Yi-Ling Tai, Chiao-Yun Chen, Yin Fang, Yi-Chien Chuang, Ching-Lin Kao and 14 more

Abstract read
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In one paragraph

Article in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

24 authors.

Shiau-Chi ChenInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Neng-Jie ZengInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Grace Y LiuInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Hsien-Chu WangInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Tzu-Ying LinInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Yi-Ling TaiInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Chiao-Yun ChenInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Yin FangInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Yi-Chien ChuangInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Ching-Lin KaoInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Hsuan ChengInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Bing-Huang WuInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Pin-Chiao SunInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Odvogmed BayansanInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Yu-Ting ChiuInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Chi-Hsuan ShihInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Wen-Hong ChungInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Jia-Bin YangInstitute of Molecular and Cellular Biology, National Taiwan University, Taipei, 106319, Taiwan.
Lily Hui-Ching WangInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Po-Han ChiangInstitute of Biomedical Engineering, National Yang Ming Chiao Tung University, Hsinchu, 300093, Taiwan.
Chun-Hao ChenInstitute of Molecular and Cellular Biology, National Taiwan University, Taipei, 106319, Taiwan.
Oliver I WagnerInstitute of Molecular and Cellular Biology, National Tsing Hua University, Hsinchu, 300044, Taiwan.
Yi-Ching WangDepartment of Pharmacology, College of Medicine, National Cheng Kung University, Tainan, 701401, Taiwan.
Yu-Chun LinInstitute of Molecular Medicine, National Tsing Hua University, Hsinchu, 300044, Taiwan.ORCID 0000-0002-9629-7560

Funding

National Health Research Institutes, Taiwan NHRI-EX113-11124BINational Tsing Hua University 113Q2743E1National Tsing Hua University 113QI019E1
6 · The paper itself

Abstract

Intracellular trafficking, an extremely complex network, dynamically orchestrates nearly all cellular activities. A versatile method that enables the manipulation of target transport pathways with high spatiotemporal accuracy in vitro and in vivo is required to study how this network coordinates its functions. Here, a new method called RIVET (Rapid Immobilization of target Vesicles on Engaged Tracks) is presented. Utilizing inducible dimerization between target vesicles and selective cytoskeletons, RIVET can spatiotemporally halt numerous intracellular trafficking pathways within seconds in a reversible manner. Its highly specific perturbations allow for the real-time dissection of the dynamic relationships among different trafficking pathways. Moreover, RIVET is capable of inhibiting receptor-mediated endocytosis. This versatile system can be applied from the cellular level to whole organisms. RIVET opens up new avenues for studying intracellular trafficking under various physiological and pathological conditions and offers potential strategies for treating trafficking-related disorders.

Indexed as

EndocytosisAnimalsHumansProtein Transportchemical‐inducible dimerizationcytoskeletonoptogeneticsreceptor‐mediated endocytosisvesicular traffickingvirus entry

Identifiers

PMID39401410
PMCPMC11615828

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.