Evidence map›Paper›PMID 39401365›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Abortive infection of bat fibroblasts with SARS-CoV-2.

Punam Bisht, Michael D Gallagher, M Inmaculada Barrasa, Julie Boucau, Alfred Harding, Marion Déjosez, Carlos Godoy-Parejo, Margaret E Bisher, Giovanni de Nola, Abigail K R Lytton-Jean and 3 more

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed.

  1. Review
  2. Chiropteran (Animals : an open access journal from MDPI · 2026
    Article
  3. Article
  4. Article
  5. A survey of SARS-CoV-2 tropism.Infectious diseases & immunity · 2025
    Review
  6. Review
  7. Article
  8. Abortive infection of bat fibroblasts with SARS-CoV-2.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Punam BishtWhitehead Institute for Biomedical Research, Cambridge, MA 02142.
Michael D GallagherWhitehead Institute for Biomedical Research, Cambridge, MA 02142.ORCID 0000-0002-2109-1293
M Inmaculada BarrasaWhitehead Institute for Biomedical Research, Cambridge, MA 02142.ORCID 0000-0003-3393-4814
Julie BoucauRagon Institute of Massachusetts General Hospital, Massachusetts Institute of Technology and Harvard, Cambridge, MA 02139.ORCID 0000-0001-6731-7238
Alfred HardingInstitute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.
Marion DéjosezDepartment of Cell, Developmental, and Regenerative Biology, and Black Family Stem CellInstitute, Icahn School of Medicine at Mount Sinai, New York, NY 10502.
Carlos Godoy-ParejoDepartment of Cell, Developmental, and Regenerative Biology, and Black Family Stem CellInstitute, Icahn School of Medicine at Mount Sinai, New York, NY 10502.
Margaret E BisherDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
Giovanni de NolaDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
Abigail K R Lytton-JeanDavid H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139.
Lee GehrkeInstitute for Medical Engineering and Sciences, Massachusetts Institute of Technology, Cambridge, MA 02139.ORCID 0000-0002-9387-8212
Thomas P ZwakaDepartment of Cell, Developmental, and Regenerative Biology, and Black Family Stem CellInstitute, Icahn School of Medicine at Mount Sinai, New York, NY 10502.
Rudolf JaenischWhitehead Institute for Biomedical Research, Cambridge, MA 02142.

Funding

The impact of HIV viral diversity and cellular immunity on HIV pathogenesisP30AI060354 · NIAID · HARVARD UNIVERSITY (MEDICAL SCHOOL) · PI RAJESH T GANDHI · 2004 to 2026
$94.4M
VIRUS PRODUCTION COREP30CA014051 · NCI · MASSACHUSETTS INSTITUTE OF TECHNOLOGY · PI Paula T Hammond · 1985 to 2026
$93.9M
Transcriptional condensates, epigenetic editing and Rett SyndromeR01MH104610 · NIMH · WHITEHEAD INSTITUTE FOR BIOMEDICAL RES · PI JAENISCH, RUDOLF, YOUNG, RICHARD · 2014 to 2023
$7.4M
HHS | NIH | National Institute of Neurological Disorders and Stroke (NINDS) 5R01MH104610-24Living Stones Foundation GiftNCI NIH HHS P30 CA014051NIAID NIH HHS P30 AI060354NIMH NIH HHS R01 MH104610
6 · The paper itself

Abstract

Bats are tolerant to highly pathogenic viruses such as Marburg, Ebola, and Nipah, suggesting the presence of a unique immune tolerance toward viral infection. Here, we compared severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection of human and bat (

Indexed as

Angiotensin-Converting Enzyme 2ChiropteraCOVID-19FibroblastsSARS-CoV-2AnimalsHumansInduced Pluripotent Stem CellsVirus ReplicationACE2 protein, humanAngiotensin-Converting Enzyme 2abortive infectionbat cellsinnate immune systemSARS-CoV-2

Identifiers

PMID39401365
PMCPMC11513954

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.