Evidence map›Paper›PMID 39401359›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2024

Helical coiled nucleosome chromosome architectures during cell cycle progression.

Angus McDonald, Cornelis Murre, John W Sedat

Abstract read
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Angus McDonaldMicron School of Materials Science and Engineering, Boise State University, Boise, ID 83725-2090.
Cornelis MurreDivision of Biological Sciences, University of California San Diego, La Jolla, CA 92093.
John W SedatDepartment of Biochemistry and Biophysics, University of California, San Francisco, CA 94158.

Funding

The 3D-Structures of the Immunoglobulin Heavy Chain LocusR01AI082850 · NIAID · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI MURRE, CORNELIS · 2009 to 2024
$5.4M
HHS | NIH | National Institute of General Medical Sciences (NIGMS) ro1ai082859 ro1ai082850 us1-bsf2019280NIAID NIH HHS R01 AI082850
6 · The paper itself

Abstract

Recent studies showed an interphase chromosome architecture-a specific coiled nucleosome structure-derived from cryopreserved EM tomograms, and dispersed throughout the nucleus. The images were computationally processed to fill in the missing wedges of data caused by incomplete tomographic tilts. The resulting structures increased z-resolution enabling an extension of the proposed architecture to that of mitotic chromosomes. Here, we provide additional insights into the chromosome architecture that was recently published [M. Elbaum et al.,

Indexed as

InterphaseNucleosomesCell CycleCentromereChromosomesHumansMitosisNucleosomeschromosome architecturecomputer modelingnuclear structure

Identifiers

PMID39401359
PMCPMC11513933

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.