Evidence map›Paper›PMID 39401331›Full record

ArticleOcular immunology and inflammation2024

Risk of Intestinal Complications, Extraintestinal Morbidity, and Mortality in Patients with Crohn's Disease and Ocular Involvement.

Amer F Alsoudi, Karen M Wai, Euna Koo, Ryan A McConnell, Nathan H Pham, Brian K Do, Cassie A Ludwig, Andrea L Kossler, Prithvi Mruthyunjaya, Ehsan Rahimy

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Ocular immunology and inflammation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Observational
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Amer F AlsoudiDepartment of Ophthalmology, Baylor College of Medicine, Houston, Texas, USA.
Karen M WaiByers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Euna KooByers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Ryan A McConnellDepartment of Gastroenterology, Palo Alto Medical Foundation, Palo Alto, California, USA.
Nathan H PhamDepartment of Gastroenterology, University of Washington Seattle, Seattle, Washington, USA.
Brian K DoDepartment of Ophthalmology, MedStar Georgetown University Hospital, Washington, District of Columbia, USA.ORCID 0000-0003-1707-6899
Cassie A LudwigByers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Andrea L KosslerByers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Prithvi MruthyunjayaByers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.
Ehsan RahimyByers Eye Institute, Department of Ophthalmology, Stanford University School of Medicine, Palo Alto, California, USA.

Funding

Stanford Vision Research CoreP30EY026877 · NEI · STANFORD UNIVERSITY · PI Jeffrey L Goldberg · 2017 to 2026
$8.0M
NEI NIH HHS P30 EY026877
6 · The paper itself

Abstract

purposePatients with Crohn's disease (CD) and subsequent ocular manifestations may have worse outcomes when compared to matched patients with CD without ocular disease.

methodsIn this retrospective cohort study, an aggregated electronic health records research network, TriNetX (Cambridge, MA, USA), was used to identify patients diagnosed with CD stratified by the presence or absence of ocular involvement with at least 1 year of follow-up. Propensity score matching (PSM) was performed to control for baseline demographics and medical comorbidities.

resultsPatients with CD with ocular disease showed a greater risk of undergoing bowel resections (RR: 2.06, 95% CI: 1.48-2.85,

conclusionsPatients who have CD and subsequent ocular involvement have an increased risk of local intestinal complications, extraintestinal morbidity, and cardiovascular complications when compared to patients with CD without ocular involvement.

Indexed as

Crohn DiseaseAdultEye DiseasesFemaleFollow-Up StudiesHumansIntestinal DiseasesMaleMiddle AgedMorbidityRetrospective StudiesRisk FactorsCrohn’s diseaseextraintestinal manifestationsimmunomodulatory therapyinflammatory bowel diseasemortalitymyocardial infarction

Identifiers

PMID39401331
PMCPMC13318400

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.