Evidence map›Paper›PMID 39401278›Full record

ArticleCirculation2024

Sustained but Decoyed Activation of the JAK1-STAT Pathway by Aberrant Protein Aggregation Exacerbates Proteotoxicity.

Mingqi Cai, Bo Pan, Peng Xiao, Mark Bouska, Megan T Lewno, Yu Xing, Erliang Zeng, Huiyun Liang, Faqian Li, Xiang Gao and 1 more

Erratum issuedAbstract readLetter
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

11 authors.

Mingqi CaiDivision of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion (M.C., B.P., P.X., M.B., M.T.L., X.W.).ORCID 0000-0001-5690-1543
Bo PanDivision of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion (M.C., B.P., P.X., M.B., M.T.L., X.W.).ORCID 0000-0002-5705-5446
Peng XiaoDivision of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion (M.C., B.P., P.X., M.B., M.T.L., X.W.).ORCID 0009-0006-2737-4573
Mark BouskaDivision of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion (M.C., B.P., P.X., M.B., M.T.L., X.W.).ORCID 0000-0001-5019-3224
Megan T LewnoDivision of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion (M.C., B.P., P.X., M.B., M.T.L., X.W.).
Yu XingDepartment of Computer Science, Loyola University Chicago, IL (Y.X.).ORCID 0009-0001-5653-0137
Erliang ZengDivision of Biostatistics and Computational Biology, University of Iowa College of Dentistry, Iowa City (E.Z.).
Huiyun LiangDepartment of Pathology and Laboratory Medicine, Joe R. and Teresa Lozano Long School of Medicine, University of Texas Health Science Center at San Antonio (H.L., F.L.).
Faqian LiDepartment of Pathology and Laboratory Medicine, Joe R. and Teresa Lozano Long School of Medicine, University of Texas Health Science Center at San Antonio (H.L., F.L.).ORCID 0000-0002-9954-095X
Xiang GaoDepartment of Medicine, Stritch School of Medicine, Loyola University Chicago, Maywood, IL (X.G.).ORCID 0000-0002-1864-837X
Xuejun WangDivision of Basic Biomedical Sciences, University of South Dakota Sanford School of Medicine, Vermillion (M.C., B.P., P.X., M.B., M.T.L., X.W.).ORCID 0000-0001-9267-1343

Funding

Ubiquitin receptors and cardiac proteotoxicityR01HL072166 · NHLBI · UNIVERSITY OF SOUTH DAKOTA · PI WANG, XUEJUN · 2003 to 2023
$6.9M
Cardiac Pathophysiology of Proteasome PhosphoregulationR01HL153614 · NHLBI · UNIVERSITY OF SOUTH DAKOTA · PI XUEJUN WANG · 2020 to 2026
$2.9M
TCF7L2 isoforms in canonical Wnt signaling during cardiac hypertrophy and failureR01HL153403 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI LI, FAQIAN · 2021 to 2025
$2.4M
Priming the proteasome to protect against aging and Alzheimer's diseaseRF1AG072510 · NIA · UNIVERSITY OF SOUTH DAKOTA · PI WANG, HONGMIN, WANG, XUEJUN · 2022 to 2022
$1.6M
Priming the proteasome to protect against aging and Alzheimer's diseaseR01AG072510 · NIA · UNIVERSITY OF SOUTH DAKOTA · PI XUEJUN WANG, Hongmin Wang · 2025 to 2026
$1.0M
American Heart Association-American Stroke Association 20TPA35490091NHLBI NIH HHS R01 HL072166NHLBI NIH HHS R01 HL153403NHLBI NIH HHS R01 HL153614NIA NIH HHS R01 AG072510NIA NIH HHS RF1 AG072510
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Janus Kinase 1Signal TransductionAnimalsHumansMiceProtein AggregatesProtein Aggregation, PathologicalSTAT Transcription FactorsJAK1 protein, humanJanus Kinase 1Protein AggregatesSTAT Transcription FactorsJanus kinase 1Janus kinase inhibitorsproteasome endopeptidase complexprotein aggregation, pathologicalproteostasis deficienciesSTAT transcription factorsubiquitin

Identifiers

PMID39401278
PMCPMC11483158

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.