Evidence map›Paper›PMID 39401137›Full record

ArticleNeuropsychopharmacology reports2024

Association between overweight and central interleukin-6 in a nonclinical adult population.

Takako Enokida, Kotaro Hattori, Chiori Maeda, Takahiro Tomizawa, Hiroshi Kunugi

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Neuropsychopharmacology reports, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Takako EnokidaDepartment of Bioresources, Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Kotaro HattoriDepartment of Bioresources, Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID 0000-0002-4411-2317
Chiori MaedaDepartment of Bioresources, Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Takahiro TomizawaDepartment of Bioresources, Medical Genome Center, National Center of Neurology and Psychiatry, Tokyo, Japan.
Hiroshi KunugiDepartment of Mental Disorder Research, National Institute of Neuroscience, National Center of Neurology and Psychiatry, Tokyo, Japan.ORCID 0000-0002-7209-3790

Funding

Intramural Research Grant (3-1) for Neurological and Psychiatric Disorders of the NCNP
6 · The paper itself

Abstract

aimOverweight is associated with low-grade systemic inflammation. However, its effect on neuroinflammation remains unclear. We examined the possible association between overweight and neuroinflammation using cerebrospinal fluid (CSF) in a nonclinical adult population in Japan.

methodsCSF and plasma levels of interleukin-1β (IL-1β), interleukin-6 (IL-6), tumor necrosis factor-α (TNF-α), plasma levels of C-reactive protein (CRP), and leptin were measured in nonclinical adult participants (35 males and 34 females) who had no current or past history of neuropsychiatric diseases. We performed partial correlation analyses with sex and age as covariates between the body mass index (BMI) and the inflammatory markers and compared them between overweight and nonoverweight participants.

resultsThe BMI significantly correlated with CSF levels of IL-6 (rs = 0.32, p = 0.009), plasma levels of CRP (rs = 0.30, p = 0.016), IL-1β (rs = 0.29, p = 0.019), IL-6 (rs = 0.25, p = 0.042), TNF-α (rs = 0.43, p < 0.001), and leptin (rs = 0.72, p < 0.001). Overweight participants (BMI ≧ 25) had significantly higher CSF levels of IL-6 (p < 0.001), plasma levels of IL-1β (p = 0.023), TNF-α (p < 0.001), and leptin (p < 0.001) than the nonoverweight participants.

conclusionOverweight is associated with central IL-6, a marker for neuroinflammation, as well as systemic inflammation markers, even in a nonclinical population.

Indexed as

Body Mass IndexC-Reactive ProteinInterleukin-6LeptinOverweightAdultBiomarkersFemaleHumansInterleukin-1betaJapanMaleMiddle AgedTumor Necrosis Factor-alphaYoung AdultBiomarkersC-Reactive ProteinIL6 protein, humanInterleukin-1betaInterleukin-6LEP protein, humanLeptinTumor Necrosis Factor-alphabody mass indexcerebrospinal fluidinterleukine‐6neuroinflammationobesity

Identifiers

PMID39401137
PMCPMC11609746

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.