Evidence map›Paper›PMID 39401075›Full record

ArticleeLife2024

Robust optogenetic inhibition with red-light-sensitive anion-conducting channelrhodopsins.

Johannes Oppermann, Andrey Rozenberg, Thomaz Fabrin, Cristian González-Cabrera, Rafael Parker, Oded Béjà, Matthias Prigge, Peter Hegemann

Abstract read
In one paragraph

Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Apusomonad rhodopsins: A new family of ultraviolet to blue light-absorbing rhodopsin channels.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  4. Article
  5. Blue-shifted ancyromonad channelrhodopsins for multiplex optogenetics.bioRxiv : the preprint server for biology · 2025
    Article
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Johannes OppermannInstitut für Biologie, Experimentelle Biophysik, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0002-3442-1458
Andrey Rozenberg *Faculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel.ORCID https://orcid.org/0000-0001-9534-2297
Thomaz Fabrin *Research Group Neuromodulatory Networks, Leibniz Institute for Neurobiology, Magdeburg, Germany.
Cristian González-CabreraResearch Group Neuromodulatory Networks, Leibniz Institute for Neurobiology, Magdeburg, Germany.ORCID https://orcid.org/0000-0003-0515-0254
Rafael ParkerResearch Group Neuromodulatory Networks, Leibniz Institute for Neurobiology, Magdeburg, Germany.ORCID https://orcid.org/0009-0000-0770-0438
Oded BéjàFaculty of Biology, Technion - Israel Institute of Technology, Haifa, Israel.ORCID https://orcid.org/0000-0001-6629-0192
Matthias PriggeResearch Group Neuromodulatory Networks, Leibniz Institute for Neurobiology, Magdeburg, Germany.ORCID https://orcid.org/0000-0002-4923-0056
Peter HegemannInstitut für Biologie, Experimentelle Biophysik, Humboldt-Universität zu Berlin, Berlin, Germany.ORCID https://orcid.org/0000-0003-3589-6452

Funding

Alexander von Humboldt-Stiftung 99999.001756/2014-01Aligning Science Across Parkinson's ASAP-020505Deutsche Forschungsgemeinschaft SFB 1078 B2 221545957EU Joint Programme - Neurodegenerative Disease Research JPco-FuND - NiPARKIsrael Science Foundation 3131/20Leibniz-Gemeinschaft Program 'BestMinds' MP J28/2017 SheLi
6 · The paper itself

Abstract

Channelrhodopsins (ChRs) are light-gated ion channels widely used to optically activate or silence selected electrogenic cells, such as individual brain neurons. Here, we describe identifying and characterizing a set of anion-conducting ChRs (ACRs) from diverse taxa and representing various branches of the ChR phylogenetic tree. The

Indexed as

ChannelrhodopsinsLightNeuronsOptogeneticsAnimalsAnionsHumansMicePhylogenyAnionsChannelrhodopsinsanion-conducting channelrhodopsinschannelrhodopsinslow light sensitivitymetagenomicsmouseneurosciencered-light optogenetics

Identifiers

PMID39401075
PMCPMC11473104

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.