ArticleeLife2024
Operation regimes of spinal circuits controlling locomotion and the role of supraspinal drives and sensory feedback.
Article in eLife, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed.
- Reflex and functional responses to distal tibial/medial plantar nerve electrical stimulation in the treadmill-locomoting spinal cat.Journal of neurophysiology · 2026Article
- Modeling framework disentangles cerebellar mechanisms in speech feedback control, revealing trade-offs reshaped by degeneration.bioRxiv : the preprint server for biology · 2026Article
- Blue plaque review series: Thomas Graham Brown: Before his time.Experimental physiology · 2026Review
- Synergy of postural adaptation and exteroception for robust CPG-driven quadrupedal locomotion.Scientific reports · 2026Article
- Speed-Dependent Turning Strategies in Quadrupedal Locomotion: Insights from Computational Modeling.bioRxiv : the preprint server for biology · 2026Article
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- Mechanisms and Applications of Conductive Biomaterials in Spinal Cord Injury Repair.Biomaterials research · 2026Review
- Speed-dependent turning strategies in quadrupedal locomotion: insights from computational modeling.Frontiers in bioengineering and biotechnology · 2026Article
- A spinal network of proprioceptive reflexes can produce a variety of bipedal gaits.Communications biology · 2025Article
- Mechanisms of adaptive interlimb coordination to sudden ground loss: a neuromusculoskeletal modeling study.bioRxiv : the preprint server for biology · 2025Article
- Speed-dependent locomotor adjustments following staggered thoracic lateral hemisections in adult cats.Journal of neurophysiology · 2025Article
- Spinal interneuron population dynamics underlying flexible pattern generation.Nature communications · 2025Article
- Precise limb-speed afference reveals rhythmogenic drive modality and declines with age.Research square · 2025Article
- Effects of spinal transection and locomotor speed on muscle synergies of the cat hindlimb.The Journal of physiology · 2025Article
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- Operation of spinal sensorimotor circuits controlling phase durations during tied-belt and split-belt locomotion after a lateral thoracic hemisection.bioRxiv : the preprint server for biology · 2024Article
- Sensory feedback and central neuronal interactions in mouse locomotion.Royal Society open science · 2024Article
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5 authors.
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Abstract
Locomotion in mammals is directly controlled by the spinal neuronal network, operating under the control of supraspinal signals and somatosensory feedback that interact with each other. However, the functional architecture of the spinal locomotor network, its operation regimes, and the role of supraspinal and sensory feedback in different locomotor behaviors, including at different speeds, remain unclear. We developed a computational model of spinal locomotor circuits receiving supraspinal drives and limb sensory feedback that could reproduce multiple experimental data obtained in intact and spinal-transected cats during tied-belt and split-belt treadmill locomotion. We provide evidence that the spinal locomotor network operates in different regimes depending on locomotor speed. In an intact system, at slow speeds (<0.4 m/s), the spinal network operates in a non-oscillating state-machine regime and requires sensory feedback or external inputs for phase transitions. Removing sensory feedback related to limb extension prevents locomotor oscillations at slow speeds. With increasing speed and supraspinal drives, the spinal network switches to a flexor-driven oscillatory regime and then to a classical half-center regime. Following spinal transection, the model predicts that the spinal network can only operate in the state-machine regime. Our results suggest that the spinal network operates in different regimes for slow exploratory and fast escape locomotor behaviors, making use of different control mechanisms.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.