ArticleMovement disorders clinical practice2024
Clinicodemographic and Genetic Modifier Correlation in an X-Linked Dystonia-Parkinsonism Cohort from Mindanao.
Article in Movement disorders clinical practice, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Disability weight and estimated disability-adjusted life years of patients with X-linked dystonia-parkinsonism.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- Striatal hyperechogenicity as an ultrasound imaging marker for prodromal X-linked dystonia-parkinsonism.NPJ Parkinson's disease · 2026Article
- Caring for persons with X-linked dystonia-parkinsonism in Metro Manila: insights into the burden of family caregivers.Journal of neural transmission (Vienna, Austria : 1996) · 2026Article
- The Clinical, Genetic, Psychosocial, and Care Landscape of X-Linked Dystonia-Parkinsonism in Filipino Men: A Scoping Review.American journal of men's healthArticle
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Authors and funding
11 authors.
Funding
Abstract
backgroundX-linked dystonia-parkinsonism (XDP), a neurodegenerative movement disorder endemic to the Philippines, is primarily investigated in patients from Panay Island and the Greater Manila area. However, individuals residing in geographically distant regions may exhibit different clinical or genetic characteristics compared to those documented in earlier reports.
objectiveThe aim was to investigate the relationship of XDP clinical features in a Mindanao cohort with modifiers of age at onset (AAO) variability and utilization of a previously reported AAO model.
methodsWe investigated clinical and genetic features in 27 XDP patients from southern Mindanao. In all patients, we genotyped the 4 polymorphisms linked to AAO.
resultsThe XDP-relevant hexanucleotide repeat number significantly correlated with AAO in the 27 patients and explained about 68% of AAO variability. There is no statistical difference between the predicted and actual AAO.
conclusionThe AAO model may provide reliable predictions by employing the effect of XDP genetic modifiers of AAO variability.
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