Evidence map›Paper›PMID 39400909›Full record

ReviewActa paediatrica (Oslo, Norway : 1992)2025

Markers of consciousness in infants: Towards a 'cluster-based' approach.

Joel Frohlich, Tim Bayne

Abstract readReview
In one paragraph

Review in Acta paediatrica (Oslo, Norway : 1992), 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Joel FrohlichIDM/fMEG Center of the Helmholtz Center Munich at the University of Tübingen, University of Tübingen, Tübingen, Germany.ORCID 0000-0001-8382-4344
Tim BayneSchool of Philosophy, History, and Indigenous Studies (SOPHIS), Monash University, Melbourne, Victoria, Australia.

Funding

Canadian Institute for Advanced ResearchMonash University's Arts Faculty
6 · The paper itself

Abstract

As recently as the 1980s, it was not uncommon for paediatric surgeons to operate on infants without anaesthesia. Today, the same omission would be considered criminal malpractice, and there is an increased concern with the possibility of consciousness in the earliest stage of human infancy. This concern reflects a more general trend that has characterised science since the early 1990s of taking consciousness seriously. While this attitude shift has opened minds towards the possibility that our earliest experiences predate our first memories, convincing demonstrations of infant consciousness remain challenging given that infants cannot report on their experiences. Furthermore, while many behavioural and neural markers of consciousness that do not rely on language have been validated in adults, no one specific marker can be confidently translated to infancy. For this reason, we have proposed the 'cluster-based' approach, in which a consensus of evidence across many markers, all pointing towards the same developmental period, could be used to argue convincingly for the presence of consciousness.

conclusionWe review the most promising markers for early consciousness, arguing that consciousness is likely to be in place by 5 months of age if not earlier.

Indexed as

ConsciousnessBiomarkersChild DevelopmentHumansInfantBiomarkersbiomarkersconsciousnessfoetusinfantneonateneuroimaging

Identifiers

PMID39400909
PMCPMC11706756

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.