ArticleAdvances in experimental medicine and biology2024
Relationship Between Dementia and Systemic Metabolic Disorders.
Article in Advances in experimental medicine and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
1 citing paper in PubMed.
- A collaborative framework for uncovering molecular and cellular drivers of VCID: Foundations for future interventions in dementia.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
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Authors and funding
1 author.
Funding
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Abstract
Recent research has linked systemic metabolic disorders to cognitive decline and dementia risk, including Alzheimer's. This is suspected to be due to lifestyle-related vascular impairments from atherosclerosis and other factors, such as malnutrition and anaemia. Applying deep learning using 2897 cases from a rehabilitation hospital and health screenings, we trained a model to predict cognitive function [mini-mental state examination (MMSE) scores] and brain atrophy [Brain Healthcare Quotient (BHQ) scores] from basic blood tests and age. The deep learning model accurately estimated MMSE and BHQ from these inputs, with age, nutritional information, and organ function indicators being top predictors. These findings highlight the relationship of dementia with systemic metabolic disorders and suggest the potential of using routine blood tests for dementia risk assessment. Furthermore, personalised dietary interventions could be tailored based on blood test anomalies. This holistic view mirrors traditional Chinese medicine, which considers brain disorders systemic, that is related to vital organs but not the brain itself.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.