Evidence map›Paper›PMID 39400801›Full record

ArticleAdvances in experimental medicine and biology2024

Comparison of Secondary Ischaemia Incidence, Intracranial Pressure, and Cerebrovascular Reactivity Dynamics During Intrahospital Transportation of Severe TBI Patients.

Alex O Trofimov, Kseniia A Trofimova, Edwin M Nemoto, Oxana Semyachkina-Glushkovskaya, Olga A Bragina, Denis E Bragin

Abstract readComparative Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Advances in experimental medicine and biology, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Alex O TrofimovDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Kseniia A TrofimovaDepartment of Neurological Diseases, Privolzhsky Research Medical University, Nizhny Novgorod, Russia.
Edwin M NemotoDepartment of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA.
Oxana Semyachkina-GlushkovskayaSaratov State University, Saratov, Russia.
Olga A BraginaLovelace Biomedical Research Institute, Albuquerque, NM, USA.
Denis E BraginDepartment of Neurology, University of New Mexico School of Medicine, Albuquerque, NM, USA.

Funding

University of New Mexico (UNM) Center for Brain Recovery and RepairP20GM109089 · NIGMS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI SHUTTLEWORTH, CLAUDE W · 2015 to 2024
$22.7M
Brain Injury Treatment by Modulation of Hemodynamics With Blood Soluble Drag Reducing MoleculesR01NS112808 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2019 to 2023
$2.1M
The mechanisms of cerebral microcirculation response to transcranial stimulation.R21AG089266 · NIA · LOVELACE BIOMEDICAL RESEARCH INSTITUTE · PI BRAGINA, OLGA A · 2024 to 2024
$597k
Stroke Treatment by Modulation of Hemodynamics with Drag Reducing MoleculesR21NS091600 · NINDS · UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR · PI BRAGIN, DENIS E. · 2015 to 2016
$423k
NIA NIH HHS R21 AG089266NIGMS NIH HHS P20 GM109089NINDS NIH HHS R01 NS112808NINDS NIH HHS R21 NS091600
6 · The paper itself

Abstract

The aims of the study were to evaluate posttraumatic cerebral ischaemia (PTCI) incidence in severe traumatic brain injury (TBI) patients and to assess the intracranial pressure (ICP) and cerebrovascular reactivity dynamics during intrahospital transportation (IT). MATERIALS: A total of 153 severe TBI patients and 182 IT were included. The mean Glasgow Coma Scale (GCS) score was 6.7 ± 2.1. ICP and arterial pressure were invasively monitored, and an improved pressure reactivity index (iPRx) was calculated from the measured parameters. Statistical analysis was done using Student's t-criterion and Wilcoxon criterion where appropriate.

resultsPerfusion computed tomography (PCT) revealed a neuroimaging PTCI pattern in all 153 severe TBI patients (100%). In 58 patients (37.9%), ischaemia extended to both hemispheres; in 95 patients (62.1%), it affected only one hemisphere. The mean ICP during IT was significantly higher (26.1 ± 13.5 mm Hg, p < 0.001) than before the IT (19.9 ± 5.3 mm Hg). All patients had increased ICP, especially during vertical movement in an elevator (maximum 75.2 mm Hg).

conclusionPTCI was detected in all severe TBI patients in coma. The IT of comatose severe TBI patients leads to a significant increase in ICP and iPRx.

Indexed as

Brain Injuries, TraumaticBrain IschemiaCerebrovascular CirculationIntracranial PressureAdultAgedFemaleGlasgow Coma ScaleHumansIncidenceMaleMiddle AgedTomography, X-Ray ComputedTransportation of PatientsYoung AdultCerebral ischaemiaIntrahospital transportPressure reactivity indexTraumatic brain injury

Identifiers

PMID39400801
PMCPMC12488195

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.