Evidence map›Paper›PMID 39400697›Full record

SynthesisInflammation research : official journal of the European Histamine Research Society ... [et al.]2024

Systemic immune inflammation index with all-cause and cause-specific mortality: a meta-analysis.

Wei Li, Xiaoning Wang, Houze Diao, Yuting Yang, Liyi Ding, Wenru Huan, Yaozhi Chen, Weiwei Cui

Abstract readMeta-AnalysisReview
PubMed Publisher
In one paragraph

Synthesis in Inflammation research : official journal of the European Histamine Research Society ... [et al.], 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it.

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  11. Premature aging in serious mental illness.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Wei Li *Department of Nutrition and Food Hygiene, School of Public Health, Jilin University, No. 1163, Xinmin Street, Changchun, China.
Xiaoning Wang *Department of blood transfusion, The First Hospital of Jilin University, Changchun, China.
Houze DiaoDepartment of Nutrition and Food Hygiene, School of Public Health, Jilin University, No. 1163, Xinmin Street, Changchun, China.
Yuting YangDepartment of Nutrition and Food Hygiene, School of Public Health, Jilin University, No. 1163, Xinmin Street, Changchun, China.
Liyi DingDepartment of Nutrition and Food Hygiene, School of Public Health, Jilin University, No. 1163, Xinmin Street, Changchun, China.
Wenru HuanDepartment of Nutrition and Food Hygiene, School of Public Health, Jilin University, No. 1163, Xinmin Street, Changchun, China.
Yaozhi ChenDepartment of Cardiovascular Diseases, The First Hospital of Jilin University, Xinmin Street 1, Changchun, 130021, China. chenyz21@mails.jlu.edu.cn.
Weiwei CuiDepartment of Nutrition and Food Hygiene, School of Public Health, Jilin University, No. 1163, Xinmin Street, Changchun, China. cuiweiwei@jlu.edu.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

importanceStudies have reported an association among systemic immune inflammation index (SII), all-cause and cause-specific mortality, but the results are inconsistent.

objectiveTo comprehensively explore the association between Systemic Immune Inflammation (SII) and the risk of all-cause mortality, cardiovascular disease (CVD), and cancer mortality. EVIDENCE REVIEW: A meta-analysis was conducted by reviewing existing literature. The search encompassed prominent databases including PubMed, Embase, Cochrane, and the Web of Science, with the cutoff date set at March 1, 2024. Furthermore, subgroup analyses and dose-response assessments were undertaken to provide a nuanced exploration of mortality risk factors.

findingsA total of 33 articles were included (427,819 participants). In the study, SII was associated with an increased risk of all-cause mortality (HR = 1.45, 95%CI [1.36,1.54], P < 0.05). SII increased the risk of CVD mortality (HR = 1.44, 95%CI [1.29,1.60], P < 0.05). The Linear independence shows that for every 100 units increase in SII, the risk of all-cause and CVD death increases by 5% and 6%. SII was not associated with a statistically significant risk of cancer death (HR = 1.09, 95%CI [0.96,1.23], P < 0.05). CONCLUSIONS AND RELEVANCE: Meta-analysis showed that SII was associated with all-cause mortality and CVD mortality. More data and basic research are needed to confirm the association.

Indexed as

Cardiovascular DiseasesInflammationNeoplasmsCause of DeathHumansRisk FactorsAll-cause mortalityCause-specific mortalityMeta-analysisSystemic immune inflammation index

Identifiers

PMID39400697

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.