ArticleQuality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation2025
Bidirectional association between frailty and quality of life within English longitudinal study of aging.
Article in Quality of life research : an international journal of quality of life aspects of treatment, care and rehabilitation, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Psychological distress, self-determination, and social capital associated with quality of life among retirees in Sarawak: a cross-sectional structural equation modelling analysis.BMC public health · 2026Article
- Modifiable lifestyle factors and their association with depression and quality of life in community-dwelling older adults: a multicriteria index analysis.Scientific reports · 2026Article
- The mediating role of social networks and safety perceptions in the frailty-quality of life relationship among older people in rural and urban regions of Ghana.BMC public health · 2026Article
- Article
- Association between frailty status and pain, balance, and quality of life in patients with lumbar spinal stenosis.Turkish journal of medical sciences · 2026Article
- Association between frailty and quality of life, and the moderating effect of mobile, broadcast and digital media in sub-Saharan Africa: evidence from Kenya.BMC geriatrics · 2025Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
purposeThe relationship between quality of life (QoL) and frailty has previously been investigated cross-sectionally and longitudinally as unidirectional where QoL depends upon frailty and where frailty depends on QoL. Here a bidirectional relationship is examined.
methodsThis work uses a latent curve model with structured residuals to address the bidirectional association between QoL and frailty in older English people considering within-person and group levels. The study measures frailty using a functional frailty measure and quality of life using CASP-12. The sample size is 17,529.
resultsThere is a strong relationship between QoL (Quality of Life) and frailty, which is almost linear and inversely proportional over time. Although the cross-lagged coefficients from QoL to frailty and vice versa showed statistical significance, the impact was found to be minimal. The time between assessments (which are two years apart) and/or the few observations available per individual may have impacted the effect of this relationship. When accounting for gender, age, net wealth, and multimorbidity, some variations in the results were observed at the group level but not at the within-person level.
conclusionThe study provides empirical evidence that supports a bidirectional association between QoL and frailty in older individuals who reside at home. These results offer valuable insights for healthcare providers, as participants did not exhibit an advanced need for health services. Additionally, involving participants in evaluating and assessing these services enhances their effectiveness and overall benefit.
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