Evidence map›Paper›PMID 39400594›Full record

ReviewMedical oncology (Northwood, London, England)2024

The role of kinesin superfamily proteins in hepatocellular carcinoma.

Zahraa Sabah Ghnim, Morug Salih Mahdi, Suhas Ballal, Mamata Chahar, Rajni Verma, Ali M Ali Al-Nuaimi, M Ravi Kumar, Rouaida Kadhim A Al-Hussein, Mohaned Adil, Mahmood Jasem Jawad

Abstract readReview
PubMed Publisher
In one paragraph

Review in Medical oncology (Northwood, London, England), 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Article
  4. Research progress of kinesin family in neurological diseases.Frontiers in cellular neuroscience · 2025
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Zahraa Sabah GhnimCollege of Pharmacy, Al-Noor University, Mosul, Iraq.
Morug Salih MahdiCollege of MLT, Ahl Al Bayt University, Karbala, Iraq.
Suhas BallalDepartment of Chemistry and Biochemistry, School of Sciences, JAIN (Deemed to Be University), Bangalore, Karnataka, India. suhasballal614@gmail.com.
Mamata ChaharDepartment of Chemistry, NIMS Institute of Engineering & Technology, NIMS University, Jaipur, Rajasthan, India.
Rajni VermaDepartment of Applied Sciences, Chandigarh Engineering College, Chandigarh Group of Colleges, Jhanjeri, Mohali, Amritsar, Punjab, 140307, India.
Ali M Ali Al-NuaimiGilgamesh Ahliya University, Baghdad, Iraq.
M Ravi KumarDepartment of Chemistry, Raghu Engineering College, Visakhapatnam, Andhra Pradesh, 531162, India.
Rouaida Kadhim A Al-HusseinCollage of Nursing, National University of Science and Technology, Dhi Qar, 64001, Iraq.
Mohaned AdilPharmacy College, Al-Farahidi University, Baghdad, Iraq.
Mahmood Jasem JawadDepartment of Pharmacy, Al-Zahrawi University College, Karbala, Iraq.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The most prevalent form of primary liver cancer, hepatocellular carcinoma (HCC) poses a significant global health challenge due to its limited therapeutic options. Researchers are currently focused on the complex molecular landscape that governs the initiation and progression of HCC in order to identify new avenues for diagnosis, prognosis, and treatment. In the context of HCC, the Kinesin Superfamily Proteins (KIFs) have become critical regulators of cellular processes, prompting a growing interest in their function among the diverse array of molecular actors implicated in cancer. The KIFs, a family of microtubule-based molecular motors, are renowned for their essential roles in the dynamics of mitotic spindles and intracellular transport. Beyond their well-established functions in normal cellular physiology, emerging evidence indicates that dysregulation of KIFs significantly contributes to the pathogenesis of HCC. Novel therapeutic targets and diagnostic markers are revealed through the unique opportunity to comprehend the complex interplay between KIFs and the molecular events that drive HCC.

Indexed as

Carcinoma, HepatocellularKinesinsLiver NeoplasmsBiomarkers, TumorHumansBiomarkers, TumorKinesinsHepatocellular carcinomaKinesin superfamilyKinesin superfamily proteinsMetastasis

Identifiers

PMID39400594

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.