Sensitive determination of volatile nitrosamines with ambient pressure ammonium-adduct ionization mass spectrometry.

Lian Duan, Cheng Wang, Yuwei Li, Binwang Yang, Xiuqing Zheng, Jiaxu Liu, Guoxing Jing, Wenjie Liu, Jianna Yu

Abstract read

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Article in Analytical and bioanalytical chemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

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1citing papers in PubMed

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1 citing paper in PubMed.

The development of an analytical method to evaluate the nitrosamine profile in cooked ham with different preservatives and in rat feces fed with them.Analytical and bioanalytical chemistry · 2026
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9 authors.

Lian DuanCollege of Chemical Engineering, Xiangtan University, Xiangtan, 411105, China.

Cheng WangCollege of Chemical Engineering, Xiangtan University, Xiangtan, 411105, China.

Yuwei LiCollege of Chemical Engineering, Xiangtan University, Xiangtan, 411105, China.

Binwang YangCollege of Chemical Engineering, Xiangtan University, Xiangtan, 411105, China.

Xiuqing ZhengCollege of Chemical Engineering, Xiangtan University, Xiangtan, 411105, China.

Jiaxu LiuCollege of Chemical Engineering, Xiangtan University, Xiangtan, 411105, China.

Guoxing JingCollege of Chemical Engineering, Xiangtan University, Xiangtan, 411105, China.

Wenjie LiuCollege of Chemical Engineering, Xiangtan University, Xiangtan, 411105, China.

Jianna YuCollege of Chemical Engineering, Xiangtan University, Xiangtan, 411105, China. yujianna2000@sina.com.

Funding

National Natural Science Foundation of China grant number 21864021Science and Technology Program of Hunan Province 21A0091

6 · The paper itself

Abstract

In recent years, the control of volatile N-nitrosamines (NAs) has been of interest in the pharmaceutical and food industries, as many of these compounds are probable human carcinogens. Thus, rapid and trace-level quantitative determination methods are in urgent demand. In this work, ambient pressure ammonium-adduct ionization mass spectrometry was proposed for the sensitive detection of volatile nitrosamines in various pharmaceutical headspaces. The ammonium ions produced through electrospray ionization acted as reactant ions for NAs to generate ammonium-NA adduct ions and underwent in-source collision-induced dissociation to produce protonated NAs, which were detected by mass spectrometry. The ionization selectivity and sensitivity for various volatile NAs were improved significantly using the developed method, which was demonstrated by the limit of quantification (LOQ) below 52 ng L

Indexed as

Ammonium CompoundsMass SpectrometryNitrosaminesPressureSensitivity and SpecificityCalibrationHydrogenIonsLimit of DetectionMetforminVolatilizationAmmonium CompoundsHydrogenIonsMetforminNitrosaminesAmmonium-adductMass spectrometryN-nitrosaminesSelectivitySensitivity

Identifiers

PMID39400577

DOI10.1016/j.jpba.2020.113460

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.