Evidence map›Paper›PMID 39400556›Full record

ArticleASN neuro2024

Quantitative Analysis of Early White Matter Damage in Cuprizone Mouse Model of Demyelination Using 7.0 T MRI Multiparametric Approach.

Emma Friesen, Maxina Sheft, Kamya Hari, Vanessa Palmer, Shenghua Zhu, Sheryl Herrera, Richard Buist, Depeng Jiang, Xin-Min Li, Marc R Del Bigio and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in ASN neuro, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Emma FriesenDepartment of Chemistry, University of Winnipeg, Winnipeg, Canada.ORCID 0009-0006-5683-8592
Maxina SheftDepartment of Physics, University of Winnipeg, Winnipeg, Canada.
Kamya HariDepartment of Physics, University of Winnipeg, Winnipeg, Canada.
Vanessa PalmerDepartment of Biomedical Engineering, University of Manitoba, Winnipeg, Canada.
Shenghua ZhuDepartment of Neuroradiology, Massachusetts General Hospital, Boston, Massachusetts, USA.
Sheryl HerreraDepartment of Physics, University of Winnipeg, Winnipeg, Canada.
Richard BuistDepartment of Radiology, University of Manitoba, Winnipeg, Canada.
Depeng JiangDepartment of Community Health Sciences, University of Manitoba, Winnipeg, Canada.
Xin-Min LiDepartment of Psychiatry, University of Alberta, Edmonton, Canada.
Marc R Del BigioDepartment of Pathology, University of Manitoba, Winnipeg, Canada.
Jonathan D ThiessenImaging Program, Lawson Health Research Institute, London, Canada.
Melanie MartinDepartment of Physics, University of Winnipeg, Winnipeg, Canada.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Magnetic Resonance Imaging (MRI) is commonly used to follow the progression of neurodegenerative conditions, including multiple sclerosis (MS). MRI is limited by a lack of correlation between imaging results and clinical presentations, referred to as the clinico-radiological paradox. Animal models are commonly used to mimic the progression of human neurodegeneration and as a tool to help resolve the paradox. Most studies focus on later stages of white matter (WM) damage whereas few focus on early stages when oligodendrocyte apoptosis has just begun. The current project focused on these time points, namely weeks 2 and 3 of cuprizone (CPZ) administration, a toxin which induces pathophysiology similar to MS.

Indexed as

CuprizoneDemyelinating DiseasesDisease Models, AnimalMice, Inbred C57BLWhite MatterAnimalsDiffusion Tensor ImagingFemaleMagnetic Resonance ImagingMaleMiceMultiparametric Magnetic Resonance ImagingCuprizoneCuprizonedemyelinationelectron microscopymagnetization transferMRIrelaxometry

Identifiers

PMID39400556
PMCPMC11792140

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.