Evidence map›Paper›PMID 39400549›Full record

ArticleHead & neck2025

Trans Oral Robotic Surgery for HPV-Negative Oropharyngeal Squamous Cell Carcinoma: Follow-Up on Oncological and Functional Outcomes.

Khalid Azalmad, Karma Lambercy, Avinash Beharry, Nathalie Piazzon, Marie Barbesier, Margaux Dalla-Vale, Manuela Moraru, Sabina Berezowska, Christian Simon

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In one paragraph

Article in Head & neck, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Khalid AzalmadDepartment of Otolaryngology-Head and Neck Surgery, CHUV, University of Lausanne, Lausanne, Switzerland.
Karma LambercyDepartment of Otolaryngology-Head and Neck Surgery, CHUV, University of Lausanne, Lausanne, Switzerland.
Avinash BeharryDepartment of Otolaryngology-Head and Neck Surgery, CHUV, University of Lausanne, Lausanne, Switzerland.
Nathalie PiazzonDepartment of Laboratory Medicine and Pathology, Institute of Pathology, CHUV, University of Lausanne, Lausanne, Switzerland.
Marie BarbesierDepartment of Laboratory Medicine and Pathology, Institute of Pathology, CHUV, University of Lausanne, Lausanne, Switzerland.
Margaux Dalla-ValeDepartment of Otolaryngology-Head and Neck Surgery, CHUV, University of Lausanne, Lausanne, Switzerland.
Manuela MoraruDepartment of Otolaryngology-Head and Neck Surgery, CHUV, University of Lausanne, Lausanne, Switzerland.
Sabina BerezowskaDepartment of Laboratory Medicine and Pathology, Institute of Pathology, CHUV, University of Lausanne, Lausanne, Switzerland.
Christian SimonDepartment of Otolaryngology-Head and Neck Surgery, CHUV, University of Lausanne, Lausanne, Switzerland.ORCID 0000-0002-4156-9143

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe efficacy of transoral robotic surgery (TORS) for HPV-negative oropharyngeal cancers (OPSCC) is less explored, especially regarding long-term outcomes and prognostic factors.

methodsWe conducted a retrospective monocentric study on 37 patients with HPV-negative OPSCC treated with TORS with a median follow-up of 3 years, assessing survival outcomes using Kaplan-Meyer statistics and swallowing function via the functional outcome swallowing scale (FOSS). Histopathological parameters were collected either from medical records or histology slides were re-evaluated.

resultsPatients demonstrated high disease-specific survival (DSS) but lower overall survival (OS), with a cohort characterized by high comorbidity rates. Vascular invasion was a significant adverse factor for relapse-free survival (RFS) and OS, while lymphatic invasion was not. Most patients demonstrated significant preservation of swallowing function.

conclusionsTORS for HPV-negative OPSCC demonstrates high DSS and preserved swallowing function. Vascular invasion is a key prognostic factor for survival outcomes.

Indexed as

Carcinoma, Squamous CellOropharyngeal NeoplasmsRobotic Surgical ProceduresAdultAgedAged, 80 and overDeglutitionDisease-Free SurvivalFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMaleMiddle AgedNeoplasm InvasivenessPrognosishead and neck cancer—squamous cell carcinomaHPV‐negativeoropharynx cancertransoral robotic surgery

Identifiers

PMID39400549
PMCPMC11816564

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.