Evidence map›Paper›PMID 39400540›Full record

ArticleAging2024

Integrative pan-cancer analysis reveals the prognostic and immunotherapeutic value of ALKBH7 in HNSC.

Tianyu Wang, Bojian Lin, Boyu Cai, Zhiwen Cao, Caiquan Liang, Shunyu Wu, Enhong Xu, Li Li, Hu Peng, Huanhai Liu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tianyu WangDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200003, P.R. China.
Bojian LinDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200003, P.R. China.
Boyu CaiDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200003, P.R. China.
Zhiwen CaoDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200003, P.R. China.
Caiquan LiangDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200003, P.R. China.
Shunyu WuDepartment of Otolaryngology-Head and Neck Surgery, Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200011, P.R. China.
Enhong XuDepartment of Otolaryngology, Naval Medical Center, Naval Medical University, Shanghai 200052, P.R. China.
Li LiDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200003, P.R. China.
Hu PengDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200003, P.R. China.
Huanhai LiuDepartment of Otolaryngology-Head and Neck Surgery, The Second Affiliated Hospital of Naval Medical University, Naval Medical University, Shanghai 200003, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The AlkB homolog 7 (ALKBH7) is a nonheme iron (II) α-ketoglutarate-dependent dioxygenase superfamily member, which may affect the progression of several types of human cancer. However, the biological effect, especially the immune-related effect, of ALKBH7 in HNSC remains unclear. Herein, several databases were employed at first to assess the different expression of ALKBH7 as well as their relationship to the prognosis, RNA modification, DNA methylation modulation, immune microenvironment and chemotherapeutic responses of various types of cancers. We found that ALKBH7 was expressed differentially in pan-cancer, and correlated with a satisfied prognosis especially in HNSC. The expression of ALKBH7 was also associated with the level of immune cell infiltration, TMB, MSI, HRD, MMR deficiency, and DNA methyltransferases in a wide variety of cancers, which might be potentially related to the responses against chemotherapeutic agents. Next, the role of ALKBH7 in HNSC was further investigated. Western blot and immunohistochemical analysis in HNSC patients from the NMU cohort showed the reduced ALKBH7 expression level in tumor tissues.

Indexed as

Biomarkers, TumorAlkB EnzymesCell Line, TumorCell ProliferationDNA MethylationGene Expression Regulation, NeoplasticHumansImmunotherapyMitochondrial ProteinsPrognosisTumor MicroenvironmentAlkB EnzymesALKBH7 protein, humanBiomarkers, TumorMitochondrial ProteinsALKBH7biomarkerhead and neck squamous cell carcinomapan-cancerprognosistumor cell proliferation

Identifiers

PMID39400540
PMCPMC11501379

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.