Evidence map›Paper›PMID 39400348›Full record

ArticleJournal of surgical oncology2025

Incidence and Prognostic Implications of Lymphovascular Invasion in Node-Negative Pancreatic Neuroendocrine Tumors: Results From the US Neuroendocrine Study Group.

Kota Sahara, Diamantis I Tsilimigras, Yuki Homma, Jun Kawashima, Shishir K Maithel, Flavio Rocha, Sharon Weber, Ryan Fields, Kamran Idrees, George A Poultsides and 3 more

Abstract read
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In one paragraph

Article in Journal of surgical oncology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Kota SaharaDepartment of Gastroenterological Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
Diamantis I TsilimigrasDepartment of Surgery, Division of Surgical Oncology, The Ohio State University Wexner Medical Center and James Comprehensive Cancer Center, Columbus, Ohio, USA.ORCID http://orcid.org/0000-0002-3676-9263
Yuki HommaDepartment of Gastroenterological Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
Jun KawashimaDepartment of Gastroenterological Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
Shishir K MaithelDepartment of Surgery, Division of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, Georgia, USA.ORCID http://orcid.org/0000-0002-3591-8925
Flavio RochaDepartment of Surgery, Oregon Health and Sciences University, Portland, Oregon, USA.ORCID http://orcid.org/0000-0002-1656-5108
Sharon WeberDepartment of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, Wisconsin, USA.
Ryan FieldsDepartment of Surgery, Washington University School of Medicine, St. Louis, Missouri, USA.
Kamran IdreesDepartment of Surgery, Division of Surgical Oncology, Vanderbilt University, Nashville, Tennessee, USA.
George A PoultsidesDepartment of Surgery, Stanford University, Stanford, California, USA.
Cliff ChoDepartment of Surgery, Division of Hepatopancreatobiliary and Advanced Gastrointestinal Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Itaru EndoDepartment of Gastroenterological Surgery, Yokohama City University School of Medicine, Yokohama, Japan.
Timothy M PawlikDepartment of Gastroenterological Surgery, Yokohama City University School of Medicine, Yokohama, Japan.ORCID http://orcid.org/0000-0002-7994-9870

Funding

The authors received no specific funding for this work.
6 · The paper itself

Abstract

backgroundDespite the well-known prognostic role of lymph node metastasis (LNM) in pNETs, less is known about the importance of lymphovascular invasion (LVI) among patients with these tumors.

methodsPatients undergoing pancreatectomy for pNET between 2002 and 2020 were identified in the US Neuroendocrine Tumor Study Group database. Cox regression analysis was utilized to identify the impact of LVI on recurrence-free survival (RFS) among patients with node-negative pNET.

resultsAmong 853 patients who underwent resection for pNET, 214 patients (25.1%) had LNM, while 116 (13.6%) and 523 individuals (61.3%) were LVI + N0 and LVI - N0, respectively. The overall incidence of LVI among patients with N0 pNET was 18.1%; the incidence of LVI increased with increasing tumor size and Ki-67 levels (size < 2 cm and Ki-67 < 3%: 5.5%; size < 2 cm and Ki-67 ≥ 3%: 17.2%; size ≥ 2 cm and Ki-67 < 3%: 22.2%; size ≥ 2 cm and Ki-67 ≥ 3%: 43.1%, p < 0.001). Five-year RFS was highest among patients with LVI - N0 disease followed by individuals with LVI + N0 and N+ pNETs (92.8% vs. 61.6% vs. 58.3%, p < 0.001). On multivariable analysis, the presence of LVI on pathology remained independently associated with almost 2.5 times higher hazards of recurrence (HR 2.47, 05% CI 1.44-4.24) among individuals with N0 pNETs.

conclusionThe incidence of LVI varied according to tumor size and Ki-67. LVI was associated with a higher likelihood of recurrence among individuals who underwent formal pancreatic resection for N0 pNETs. LVI is an important prognostic indicator among patients with node-negative pNETs.

Indexed as

Neuroendocrine TumorsPancreatectomyPancreatic NeoplasmsAdultAgedFemaleFollow-Up StudiesHumansIncidenceLymphatic MetastasisMaleMiddle AgedNeoplasm InvasivenessNeoplasm Recurrence, LocalPrognosisRetrospective Studiesenucleationlymphovascular invasionpancreatic neuroendocrine tumorrecurrencesurvival

Identifiers

PMID39400348
PMCPMC12044284

What OpenQuestion holds

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LicenceCC BY-NC-ND
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.