Evidence map›Paper›PMID 39400323›Full record

ArticleBiochemistry2024

Crystal Structure of Caryolan-1-ol Synthase, a Sesquiterpene Synthase Catalyzing an Initial Anti-Markovnikov Cyclization Reaction.

Ramasamy P Kumar, Jason O Matos, Brandon Y Black, William H Ellenburg, Jiahua Chen, MacKenzie Patterson, Jacob A Gehtman, Douglas L Theobald, Isaac J Krauss, Daniel D Oprian

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biochemistry, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

10 authors.

Ramasamy P KumarDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0000-0002-6555-8289
Jason O MatosDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, United States.
Brandon Y BlackDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, United States.
William H EllenburgDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0000-0001-5726-1277
Jiahua ChenDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0000-0002-7573-6333
MacKenzie PattersonDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, United States.
Jacob A GehtmanDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, United States.
Douglas L TheobaldDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0000-0002-2695-8343
Isaac J KraussDepartment of Chemistry, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0000-0003-0984-4085
Daniel D OprianDepartment of Biochemistry, Brandeis University, Waltham, Massachusetts 02454, United States.ORCID 0000-0002-6520-5459

Funding

User Training and OutreachP30GM124165 · NIGMS · CORNELL UNIVERSITY · PI Nozomi Ando, J Christopher Fromme · 2018 to 2026
$34.2M
Macromolecular Structure MechanismT32GM007596 · NIGMS · BRANDEIS UNIVERSITY · PI OPRIAN, DANIEL D · 1985 to 2019
$4.5M
Evolution of enzyme structure and function viewed at atomic resolutionR01GM096053 · NIGMS · BRANDEIS UNIVERSITY · PI Douglas Lowell Theobald · 2011 to 2026
$3.6M
Macromolecular Structure, Dynamics, and MechanismT32GM135126 · NIGMS · BRANDEIS UNIVERSITY · PI JEFF GELLES, Douglas Lowell Theobald · 2020 to 2026
$2.1M
Pixel Array Detector for Macromolecular CrystallographyS10OD021527 · OD · CORNELL UNIVERSITY · PI EALICK, STEVEN E · 2016 to 2016
$2.0M
Empirically testing the accuracy and bias of ancestral protein resurrection methodsR01GM132499 · NIGMS · BRANDEIS UNIVERSITY · PI THEOBALD, DOUGLAS LOWELL · 2019 to 2022
$1.4M
NIGMS NIH HHS P30 GM124165NIGMS NIH HHS R01 GM096053NIGMS NIH HHS R01 GM132499NIGMS NIH HHS T32 GM007596NIGMS NIH HHS T32 GM135126NIH HHS S10 OD021527
6 · The paper itself

Abstract

In a continuing effort to understand reaction mechanisms of terpene synthases catalyzing initial anti-Markovnikov cyclization reactions, we solved the X-ray crystal structure of (+)-caryolan-1-ol synthase (CS) from

Indexed as

Alkyl and Aryl TransferasesCatalytic DomainSesquiterpenesBacterial ProteinsCrystallography, X-RayCyclizationModels, MolecularPolyisoprenyl PhosphatesProtein ConformationStreptomycesAlkyl and Aryl TransferasesBacterial Proteinsfarnesyl pyrophosphatePolyisoprenyl PhosphatesSesquiterpenesterpene synthase

Identifiers

PMID39400323
PMCPMC12068512

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.