Evidence map›Paper›PMID 39400011›Full record

ArticleCurrent drug delivery2025

Fecal Microbiota Transplantation Induced by Wumei Pills Improves Chemotherapy-Induced Intestinal Mucositis in BALB/c Mice by Modulating the TLR4/MyD88/NF-κB Signaling Pathway.

Dongxue Lu, Lijiang Ji, Feng Liu, Haixia Liu, Zhiguang Sun, Jing Yan, Hua Wu

Abstract read
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In one paragraph

Article in Current drug delivery, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Dongxue LuDepartment of Clinical Nutrition, Academy of Health and Rehabilitation, Academy of Acupuncture and Tuina, Nanjing University of Chinese Medicine, Jiangsu, Nanjing, 210023, China.
Lijiang JiDepartment of AnorectalSurge, Changshu Hospital Affiliated to Nanjing University of Chinese Medicine, Changshu 215500, Jiangsu province, China.
Feng LiuDepartment of Orthopaedics, Nanjing Pukou District Chinese Medicine Hospital, Nanjing, China.
Haixia LiuDepartment of Oncology, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing, China.
Zhiguang SunDepartment of Gastroenterology, Nanjing University of Chinese Medicine, Nanjing, 210023, China.
Jing YanKey Laboratory for Metabolic Diseases in Traditional Chinese Medicine, First Clinical Medical College, Nanjing University of Chinese Medicine, Nanjing, China.
Hua WuDepartment of Clinical Nutrition, Academy of Health and Rehabilitation, Academy of Acupuncture and Tuina, Nanjing University of Chinese Medicine, Jiangsu, Nanjing, 210023, China.

Funding

Natural science research project of higher education institutions in Jiangsu Province, China 23KJB360013
6 · The paper itself

Abstract

backgroundOur previous studies have found that Wumei Pills can regulate the intestinal flora to inhibit chemotherapy-induced intestinal mucositis (CIM). However, there is still insufficient evidence to confirm that intestinal flora is the main link in the regulation of CIM by Wumei Pills, and its downstream mechanism is still unclear.

methodWe first obtained the signal pathway of the intervention of Wumei Pill on CIM through network pharmacological analysis and then transplanted the bacterial solution into CIM mice, combined with Western Blot, HE, ELISA and other biological technology-related proteins and inflammatory factors.

resultsIt showed that 97 kinds of effective ingredients and 205 kinds of targets of Wumei pills were screened out and the potential mechanism of Wumei Pills on CIM may be the NF-κB signaling pathway. In contrast with the control group, the results displayed that the weight, food intake, and mice's colon length were apparently decreased in the 5-Fu group, while the diarrhea score was increased. However, FMT reversed this change, and the difference was statistically significant. Additionally, FMT could improve the pathological state of inflammatory cell infiltration in mice, reduce histopathological scores of colon and jejunum, decrease the expression levels of IL-1β, MPO, TNF-α, and IL-6, reverse the activation of signaling pathway named TLR4/Myd88/ NF-κB and down-regulate protein expression, thereby exerting its anti-inflammatory activities. Further experiments have found that FMT could reverse the decreasing of tight junction proteins and mucins caused by 5-Fu, thereby repairing the intestinal mucosal barrier, and FMT could also increase the content of acetic acid, propanoic acid, and butanoic acid in the feces of 5-Fu group.

conclusionFMT can defend the intestinal mucosal barrier integrality by increasing the content of exercise fatty acids, and its mechanism may be in connection with its inhibition of TLR4/My- D88/NF-κB signal pathway to relieve inflammation.

Indexed as

Antimetabolites, AntineoplasticDrugs, Chinese HerbalFecal Microbiota TransplantationGastrointestinal MicrobiomeMucositisAnimalsDisease Models, AnimalFluorouracilInjections, IntraperitonealIntestinal MucosaMaleMiceMice, Inbred BALB CMyeloid Differentiation Factor 88Network PharmacologyNF-kappa BAntimetabolites, AntineoplasticDrugs, Chinese HerbalFluorouracilMyd88 protein, mouseMyeloid Differentiation Factor 88NF-kappa BTlr4 protein, mouseToll-Like Receptor 4wumeichemotherapy-induced intestinal mucositisFecal bacteria transplantationintestinal mucosal barrierintestinal permeabilitynetwork pharmacologyshort-chain fatty acids.tight junctionsTLR4/My- D88/NF-κB

Identifiers

PMID39400011

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.