ArticleAdvanced functional materials2023
Soft, strong, tough, and durable bio-hydrogels via maximizing elastic entropy.
Article in Advanced functional materials, 2023. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.
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Who cites it
4 citing papers in PubMed.
- Advanced Corneal Hydrogels: From Passive Replacement to Active Regeneration and Intelligent Interaction.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Review
- Advances and Challenges in Constructing Bone Organoids Using Cells Derived from Human Pluripotent Stem Cells: A Review.Stem cell reviews and reports · 2026Review
- Molecular Creep Induced Fatigue Rupture of Fibrin Clots.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Multifunctional Porous Soft Bioelectronics.Materials today (Kidlington, England)Article
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Authors and funding
8 authors.
Funding
Abstract
Load-bearing soft tissues are soft but strong, strong yet tough. These properties can only be replicated in synthetic hydrogels, which do not have the biocomplexity required by many biomedical applications. By contrast, natural hydrogels, although retaining the native complexity, are weak and fragile. Here we present a thermomechanical casting method to achieve the mechanical capabilities of synthetic materials in biopolymer hydrogels. The thermomechanical cast and chemically crosslinked biopolymer chains form a short-range disordered but long-range ordered structure in water. Upon stretch, the disordered structure transforms to a hierarchically ordered structure. This disorder-order transformation resembles the synergy of the disordered elastin and ordered collagen in load-bearing soft tissues. As entropy drives a reverse order-disorder transformation, the hydrogels can resist repeated cycles of loads without deterioration in mechanical properties. Gelatin hydrogels produced by this method combine tissue-like tunable mechanical properties that outperform the gelatin prepared by synthetic approaches, and
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