Evidence map›Paper›PMID 39399684›Full record

ArticleResearch square2024

Escape of Kdm6a from X chromosome is detrimental to ischemic brains via IRF5 signaling.

Conelius Ngwa, Afzal Misrani, Kanaka Valli Manyam, Yan Xu, Shaohua Qi, Romana Sharmeen, Louise McCullough, Fudong Liu

Abstract readPreprint
PubMed Full text at PMC Publisher
In one paragraph

Article in Research square, 2024. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors.

Conelius NgwaThe University of Texas Health Science Center at Houston, McGovern Medical School.
Afzal MisraniThe University of Texas Health Science Center at Houston, McGovern Medical School.
Kanaka Valli ManyamThe University of Texas Health Science Center at Houston, McGovern Medical School.
Yan XuThe University of Texas Health Science Center at Houston, McGovern Medical School.
Shaohua QiThe University of Texas Health Science Center at Houston, McGovern Medical School.
Romana SharmeenThe University of Texas Health Science Center at Houston, McGovern Medical School.
Louise McCulloughThe University of Texas Health Science Center at Houston, McGovern Medical School.
Fudong LiuThe University of Texas Health Science Center at Houston, McGovern Medical School.

Funding

Contribution of the X Chromosome to Sex Differences in StrokeR01NS108779 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI LIU, FUDONG, MCCULLOUGH, LOUISE D. · 2018 to 2022
$2.7M
CD200 signaling mediates the interactions of neurons and endothelia with circulating leukocytes in strokeR01NS129977 · NINDS · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI Fudong Liu · 2023 to 2026
$2.2M
NINDS NIH HHS R01 NS108779NINDS NIH HHS R01 NS129977
6 · The paper itself

Abstract

The role of chromatin biology and epigenetics in disease progression is gaining increasing recognition. Genes that escape X chromosome inactivation (XCI) can impact neuroinflammation through epigenetic mechanisms. Our prior research has suggested that the X escapee genes

Indexed as

AgingEpigeneticsIRFIschemiaKdm6a/5cMicroglia

Identifiers

PMID39399684
PMCPMC11469404

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.